Usefulness of anthropometry and DXA in predicting intra-abdominal fat in obese men and women.
TL;DR: The prediction of IAF in obese subjects was highly dependent on sex more than in non-obese persons, whereas anthropometry had no predictive power and DXA was the only acceptable predictor of IF in obese men.
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Abstract: Objective: To investigate the usefulness of anthropometry and DXA in predicting intra-abdominal fat (IAF) in obese men and women.
Research Methods and Procedures: Observational, cross sectional study of 22 women and 18 men with a body mass index of 30 or above. IAF from 20 cm above and 10 cm below the L4 to L5 intervertebral disc was measured by magnetic resonance imaging (MRI) as a reference method. Central abdominal fat was measured from the upper border of L2 to the lower border of L4 by DXA. Waist and hip circumferences were also measured.
Results: In obese women DXA, waist circumference and waist-hip ratio were equally well correlated with IAF (r = 0.74, 0.75, and 0.70, respectively). In obese men DXA was moderately correlated with IAF measured by MRI (r = 0.46), whereas waist circumference and waist-hip ratio were not significantly correlated with IAF.
Discussion: The prediction of IAF in obese subjects was highly dependent on sex more than in non-obese persons. Anthropometry and DXA were equally useful in obese women, whereas anthropometry had no predictive power and DXA was the only acceptable predictor of IAF in obese men.
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Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart.
TL;DR: Echocardiographic assessment of epicardial adipose tissue could be a simple and practical tool for cardiovascular risk stratification in clinical practice and research and could serve as a reliable marker of visceral adiposity.
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Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
Cecilia M. Lindgren,Iris M. Heid,Joshua C. Randall,Claudia Lamina,Valgerdur Steinthorsdottir,Lu Qi,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Gudmar Thorleifsson,Cristen J. Willer,Blanca M. Herrera,Anne U. Jackson,Noha Lim,Paul Scheet,Nicole Soranzo,Nicole Soranzo,Najaf Amin,Yurii S. Aulchenko,John C. Chambers,Alexander W. Drong,Jia N.an Luan,Helen N. Lyon,Helen N. Lyon,Fernando Rivadeneira,Serena Sanna,Nicholas J. Timpson,M. Carola Zillikens,Hua Zhao Jing,Peter Almgren,Stefania Bandinelli,Amanda J. Bennett,Richard N. Bergman,Lori L. Bonnycastle,Suzannah Bumpstead,Stephen J. Chanock,Lynn Cherkas,Peter S. Chines,Lachlan J. M. Coin,Cyrus Cooper,Gabriel Crawford,Angela Doering,Anna F. Dominiczak,Alex S. F. Doney,Shah Ebrahim,Paul Elliott,Michael R. Erdos,Karol Estrada,Luigi Ferrucci,Guido Fischer,Nita G. Forouhi,Christian Gieger,Harald Grallert,Christopher J. Groves,Scott M. Grundy,Candace Guiducci,David Hadley,Anders Hamsten,Aki S. Havulinna,Albert Hofman,Rolf Holle,John W. Holloway,Thomas Illig,Bo Isomaa,Leonie C. Jacobs,Karen A. Jameson,Pekka Jousilahti,Fredrik Karpe,Johanna Kuusisto,Jaana Laitinen,G. Mark Lathrop,Debbie A Lawlor,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Mario A. Morken,Andrew P. Morris,Patricia B. Munroe,Narisu Narisu,Anna Nordström,Peter Nordström,Ben A. Oostra,Colin N. A. Palmer,Felicity Payne,John F. Peden,Inga Prokopenko,Frida Renström,Aimo Ruokonen,Veikko Salomaa,Manjinder S. Sandhu,Manjinder S. Sandhu,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Kijoung Song,Xin Yuan,Heather M. Stringham,Amy J. Swift,Tiinamaija Tuomi,Manuela Uda,Peter Vollenweider,Gérard Waeber,Chris Wallace,G. Bragi Walters,Michael N. Weedon,Jacqueline C.M. Witteman,Cuilin Zhang,Weihua Zhang,Mark J. Caulfield,Francis S. Collins,George Davey Smith,Ian N. M. Day,Paul W. Franks,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Augustine Kong,Jaspal S. Kooner,Markku Laakso,Edward G. Lakatta,Vincent Mooser,Andrew D. Morris,Leena Peltonen,Leena Peltonen,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Toshiko Tanaka,Toshiko Tanaka,Jaakko Tuomilehto,André G. Uitterlinden,Cornelia M. van Duijn,Nicholas J. Wareham,Hugh Watkins,Dawn M. Waterworth,Michael Boehnke,Panos Deloukas,Leif Groop,Leif Groop,David J. Hunter,David J. Hunter,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,David Schlessinger,H.-Erich Wichmann,Timothy M. Frayling,Gonçalo R. Abecasis,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos,Kari Stefansson,Kari Stefansson,Karen L. Mohlke,Inês Barroso,Mark I. McCarthy +155 more
TL;DR: By focusing on anthropometric measures of central obesity and fat distribution, a meta-analysis of 16 genome-wide association studies informative for adult waist circumference and waist–hip ratio identified three loci implicated in the regulation of human adiposity.
Adipose Tissue Quantification by Imaging Methods: A Proposed Classification
Wei Shen,ZiMian Wang,Mark Punyanita,Jianbo Lei,Ahmet Sinav,John G. Kral,Celina Imielinska,Robert Ross,Steven B. Heymsfield +8 more
TL;DR: An updated classification of total body and regional adipose tissue is proposed, providing a well-defined basis for correlating imaging studies of specific adipose tissues depots with molecular processes and revealing inconsistencies in the use of specific definitions.
Advanced body composition assessment: from body mass index to body composition profiling
Magnus Borga,Janne West,Jimmy D. Bell,Nicholas C. Harvey,Thobias Romu,Steven B. Heymsfield,Olof Dahlqvist Leinhard +6 more
TL;DR: The additional ability of MRI to also measure muscle volumes, muscle AT infiltration and ectopic fat, in combination with rapid scanning protocols and efficient image analysis tools, makes quantitative MRI a powerful tool for advanced body composition assessment.
492
Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
Cecilia M. Lindgren,Iris M. Heid,Joshua C. Randall,Claudia Lamina,Valgerdur Steinthorsdottir,Lu Qi,Elizabeth K. Speliotes,Gudmar Thorleifsson,Cristen J. Willer,Blanca M. Herrera,Anne U. Jackson,Noha Lim,Paul Scheet,Nicole Soranzo,Najaf Amin,Yurii S. Aulchenko,John C. Chambers,Alexander W. Drong,Jian'an Luan,Helen N. Lyon,Fernando Rivadeneira,Serena Sanna,Nicholas J. Timpson,M. Carola Zillikens,Jing Hua Zhao,Peter Almgren,Stefania Bandinelli,Amanda J. Bennett,Richard N. Bergman,Lori L. Bonnycastle,Suzannah Bumpstead,Stephen J. Chanock,Lynn Cherkas,Peter S. Chines,Lachlan J. M. Coin,Cyrus Cooper,Gabriel Crawford,Angela Doering,Anna F. Dominiczak,Alex S. F. Doney,Shah Ebrahim,Paul Elliott,Michael R. Erdos,Karol Estrada,Luigi Ferrucci,Guido Fischer,Nita G. Forouhi,Christian Gieger,Harald Grallert,Christopher J. Groves,Scott M. Grundy,Candace Guiducci,David Hadley,Anders Hamsten,Aki S. Havulinna,Albert Hofman,Rolf Holle,John W. Holloway,Thomas Illig,Bo Isomaa,Leonie C. Jacobs,Karen A. Jameson,Pekka Jousilahti,Fredrik Karpe,Johanna Kuusisto,Jaana Laitinen,G. Mark Lathrop,Debbie A Lawlor,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Mario A. Morken,Andrew P. Morris,Patricia B. Munroe,Narisu Narisu,Anna Nordström,Peter Nordström,Ben A. Oostra,Colin N. A. Palmer,Felicity Payne,John F. Peden,Inga Prokopenko,Frida Renström,Aimo Ruokonen,Veikko Salomaa,Manjinder S. Sandhu,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Kijoung Song,Xin Yuan,Heather M. Stringham,Amy J. Swift,Tiinamaija Tuomi,Manuela Uda,Peter Vollenweider,Gérard Waeber,Chris Wallace,G. Bragi Walters,Michael N. Weedon,Jacqueline C.M. Witteman,Cuilin Zhang,Weihua Zhang,Mark J. Caulfield,Francis S. Collins,George Davey Smith,Ian N.M. Day,Paul W. Franks,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Augustine Kong,Jaspal S. Kooner,Markku Laakso,Edward G. Lakatta,Vincent Mooser,Andrew D. Morris,Leena Peltonen,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Toshiko Tanaka,Jaakko Tuomilehto,André G. Uitterlinden,Cornelia M. van Duijn,Nicholas J. Wareham,Dawn M. Waterworth,Michael Boehnke,Panos Deloukas,Leif Groop,David J. Hunter,Unnur Thorsteinsdottir,David Schlessinger,H.-Erich Wichmann,Timothy M. Frayling,Gonçalo R. Abecasis,Joel N. Hirschhorn,Ruth J. F. Loos,Kari Stefansson,Karen L. Mohlke,Inês Barroso +140 more
- 01 Jun 2009
TL;DR: Vandervell Foundation and Wellcome Trust (068545/Z/02, GR072960 as discussed by the authors, GR076113, GR069224, GR086596/Z /08/Z)
476
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