Updated Antimicrobial Therapy for the Prevention and Treatment of Endocarditis: Focus on Daptomycin
Armando Gonzalez-Ruiz,Annie M. Jones +1 more
- 30 Apr 2012
- Vol. 2012, Iss: 5, pp 19-31
TL;DR: The body of evidence supporting the use of daptomycin in the treatment of infective endocarditis, including at doses above the licensed recommended dose of 6 mg/kg is increasing.
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Abstract: Infective endocarditis is associated with significant clinical mortality and morbidity. With the increasing age of the general population and use of intra-cardiac devices it is occurring mainly in people over the age of 60 with male to female ratios ranging from 3:2 to 9. The predominant causative pathogens are staphylococci, and with the increase in the number of pathogens that are either resistant or exhibit reduced susceptibility the management of infective endocarditis is increasingly challenging. Recent guidelines have included the lipopeptide, daptomycin, in their recommendations. The body of evidence supporting the use of daptomycin in the treatment of infective endocarditis, including at doses above the licensed recommended dose of 6 mg/kg is increasing. The current review summarises the current recommendations for infective endocarditis and the place of daptomycin in its management.
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Proposed Modifications to the Duke Criteria for the Diagnosis of Infective Endocarditis
Jennifer S. Li,Daniel J. Sexton,Nathan Mick,Richard E. Nettles,Vance G. Fowler,Thomas J. Ryan,Thomas M. Bashore,G. R. Corey +7 more
TL;DR: Modifications of the Duke criteria for the diagnosis of infective endocarditis are proposed, including that positive Q-fever serology should be changed to a major criterion and the minor criterion "echocardiogram consistent with IE but not meeting major criterion" should be eliminated.
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New criteria for diagnosis of infective endocarditis : Utilization of specific echocardiographic findings. Duke Endocarditis Service
TL;DR: Application of the proposed new criteria increases the number of definite diagnoses and should be useful for more accurate diagnosis and classification of patients with suspected endocarditis and provide better entry criteria for epidemiologic studies and clinical trials.
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Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century: The International Collaboration on Endocarditis-Prospective Cohort Study
David R. Murdoch,G. Ralph Corey,Bruno Hoen,José M. Miró,Vance G. Fowler,Arnold S. Bayer,Adolf W. Karchmer,Lars Olaison,Paul A. Pappas,Philippe Moreillon,Stephen T. Chambers,Vivian H. Chu,Vicenç Falcó,David Holland,Philip Jones,John L Klein,Nigel Raymond,Kerry Read,Marie Francoise Tripodi,Riccardo Utili,Andrew Wang,Christopher W. Woods,Christopher H. Cabell +22 more
TL;DR: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection, and Mortality remains relatively high.
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