Journal Article10.1016/J.HLPT.2012.07.003
UK Biobank: Current status and what it means for epidemiology
Naomi E. Allen,Cathie Sudlow,Paul Downey,Tim Peakman,John Danesh,Paul Elliott,John Gallacher,Jane Green,Paul M. Matthews,Jill P. Pell,Tim Sprosen,Rory Collins +11 more
505
TL;DR: The open-access nature of the resource will allow researchers from around the world to conduct research that leads to better strategies for the prevention, diagnosis and treatment of a wide range of life-threatening and disabling conditions.
read more
Abstract: UK Biobank is a very large prospective study which aims to provide a resource for the investigation of the genetic, environmental and lifestyle determinants of a wide range of diseases of middle age and later life. Between 2006 and 2010, over 500,000 men and women aged 40 to 69 years were recruited and extensive data on participants' lifestyles, environment, medical history and physical measures, along with biological samples, were collected. The health of the participants is now being followed long-term, principally through linkage to a wide range of health-related records, with validation and characterisation of health-related outcomes. Further enhancements are also underway to improve phenotype characterisation, including internet-based dietary assessment, biomarker measurements on the baseline blood samples and, in sub-samples of the cohort, physical activity monitoring and proposals for extensive brain and body imaging. UK Biobank is now available for use by all researchers, without exclusive or preferential access, for any health-related research that is in the public interest. The open-access nature of the resource will allow researchers from around the world to conduct research that leads to better strategies for the prevention, diagnosis and treatment of a wide range of life-threatening and disabling conditions.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population.
Anna Fry,Thomas J. Littlejohns,Catherine Sudlow,Nicola Doherty,Ligia Adamska,Tim Sprosen,Rory Collins,Naomi E. Allen +7 more
TL;DR: UK Biobank is not representative of the sampling population; there is evidence of a “healthy volunteer” selection bias; valid assessment of exposure-disease relationships may be widely generalizable and does not require participants to be Representative of the population at large.
3.2K
Multimodal population brain imaging in the UK Biobank prospective epidemiological study
Karla L. Miller,Fidel Alfaro-Almagro,Neal K. Bangerter,David L. Thomas,Essa Yacoub,Junqian Xu,Andreas J. Bartsch,Saad Jbabdi,Stamatios N. Sotiropoulos,Jesper L. R. Andersson,Ludovica Griffanti,Gwenaëlle Douaud,Thomas W. Okell,Peter Weale,Iulius Dragonu,Steve Garratt,Sarah Hudson,Rory Collins,Mark Jenkinson,Paul M. Matthews,Stephen M. Smith +20 more
TL;DR: UK Biobank brain imaging is described and results derived from the first 5,000 participants' data release are presented, which have already yielded a rich range of associations between brain imaging and other measures collected by UK Biobanks.
Million Veteran Program: A mega-biobank to study genetic influences on health and disease.
John Michael Gaziano,John Michael Gaziano,John Concato,Mary Brophy,Mary Brophy,Louis D. Fiore,Louis D. Fiore,Saiju Pyarajan,James Breeling,Stacey B. Whitbourne,Jennifer Deen,Colleen Shannon,Donald E. Humphries,Peter Guarino,Mihaela Aslan,Daniel Anderson,Rene LaFleur,Timothy R. Hammond,Kendra L. Schaa,Jennifer Moser,Grant D. Huang,Sumitra Muralidhar,Ronald M. Przygodzki,Timothy J. O'Leary +23 more
TL;DR: The Million Veteran Program, as an observational cohort study and mega-biobank in the Department of Veterans Affairs (VA) health care system, is designed to contribute to the development of precision medicine.
952
Cohort Profile: LifeLines, a three-generation cohort study and biobank
Salome Scholtens,Nynke Smidt,Morris A. Swertz,Stephan J. L. Bakker,Aafje Dotinga,Judith M. Vonk,Freerk van Dijk,Sander K R van Zon,Cisca Wijmenga,Bruce H. R. Wolffenbuttel,Ronald P. Stolk +10 more
TL;DR: The LifeLines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing.
808
Genome-wide association studies of brain imaging phenotypes in UK Biobank
Lloyd T. Elliott,Kevin Sharp,Fidel Alfaro-Almagro,Sinan Shi,Karla L. Miller,Gwenaëlle Douaud,Jonathan Marchini,Stephen M. Smith +7 more
TL;DR: Genome-wide association studies of brain imaging data from 8,428 individuals in UK Biobank show that many of the 3,144 traits studied are heritable, and genes associated with individual phenotypes are identified.
References
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.
4.5K
The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition.
Elio Riboli,Rudolf Kaaks +1 more
TL;DR: EPIC is a multi-centre prospective cohort study designed to investigate the relation between diet, nutritional and metabolic characteristics, various lifestyle factors and the risk of cancer in middle-aged men and women.
919
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,R.J. Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,R. Peto +8 more
TL;DR: BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.
912
Underestimation of Risk Associations Due to Regression Dilution in Long-term Follow-up of Prospective Studies
Robert Clarke,Martin J. Shipley,Sarah Lewington,Linda Youngman,Rory Collins,Michael Marmot,Richard Peto +6 more
TL;DR: In this paper, the authors analyzed the impact of the time interval on the magnitude of regression dilution ratios for blood pressure and blood cholesterol, based on bi-annual remeasurements over 30 years for participants in the Framingham Study (Framingham, Massachusetts) and a 26-year resurvey for a sample of men in the Whitehall Study (London, England).
835
The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine
Paul Elliott,Tim Peakman +1 more
TL;DR: The sample handling and storage protocol adopted by UK Biobank provides quality assured and validated methods that are feasible within the available funding and reflect the size and aims of the project.
Related Papers (5)
Clare Bycroft,Colin Freeman,Desislava Petkova,Desislava Petkova,Gavin Band,Lloyd T. Elliott,Kevin Sharp,Allan Motyer,Damjan Vukcevic,Olivier Delaneau,Olivier Delaneau,Jared O'Connell,Adrian Cortes,Adrian Cortes,Samantha Welsh,Alan Young,Mark Effingham,Gil McVean,Stephen Leslie,Naomi E. Allen,Peter Donnelly,Jonathan Marchini +21 more