Book Chapter10.1007/978-3-642-47083-7_207
Über die Bedeutung der Leber für die Hyperlactatämie im Schock
R. Schröder,W. K. Eltringham,J. R. W. Gumpert,M. E. Jenny,J. R. Pluth,R. M. Zollinger +5 more
- 01 Jan 1968
- pp 886-890
1
TL;DR: Gewebshypoxie fuhrt zur Bildung von Milchsaure, die aus den betroffenen Zellen heraus permeiert und sich im gesamten Wasserraum des Korpers verteilt.
read more
Abstract: Gewebshypoxie fuhrt zur Bildung von Milchsaure, die aus den betroffenen Zellen heraus permeiert und sich im gesamten Wasserraum des Korpers verteilt. Bis auf mehr als das Zehnfache kann die Milchsaurekonzentration im arteriellen Blut bei Schockzustanden unterschiedlicher Genese ansteigen. Die grose Kapazitat der Leber, Milchsaure aufzunehmen — sie ubertrifft bei weitem die Kapazitat anderer Organe, Milchsaure zu bilden — last vermuten, das diese Funktion der Leber gestort sein mus, bevor es zu einer anhaltenden Hyperlactatamie kommen kann.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The role of the liver in the development of lactic acidosis in low flow states.
TL;DR: The role of the liver in lactate metabolism in an experimental low flow state induced by cardiac tamponade was investigated in dogs and it was found that the liver was, in part, responsible for the development of lactic acidosis by impaired lactate consumption.
23
References
Appearance of excess lactate in anesthetized dogs during anemic and hypoxic hypoxia.
TL;DR: Ten anesthetized, splenectomized dogs were made progressively anemic by replacement of blood with warmed dextran to approximate hematocrits of 30, 20, 15, and 10%.
163
Splanchnic lactic acid metabolism in hyperventilation, metabolic alkalosis and shock
Michael N. Berry,James Scheuer +1 more
TL;DR: The experiments indicate that the changes in splanchnic lactic acid and glucose metabolism in hyperventilation and shock are due to hepatic ischemia and suggest that the liver may play a major role in the pathogenesis of lactic Acidosis.
75
Lactic Acid Metabolism in Hyperventilation, Metabolic Alkalosis and Shock
Michael N. Berry,James Scheuer +1 more
- 01 Jan 1967
TL;DR: In this article, the possibility that hyperlactatemia is associated with hyperventilation and a hypocapnia has been established, although the cause of the lactate accumulation has not been established.
64
Lactate metabolism in the isolated perfused rat liver
TL;DR: The method of isolated perfused organs is selected, the same technique with which more than 50 years ago Embden proved the conversion of glucose to lactate in mammalian livers, because it combines in many respects the advantages of in uiuo and in uitro experiments.
24
Regional differences of the lactate-pyruvate response to progressive arterial hypoxemia.
TL;DR: A nonuniform contribution of different organs to arterial blood changes during progressive arterial hypoxemia is demonstrated and the hypothesis of a predominant role of the liver and possibly skeletal muscle in the early arterial changes of lactate and pyruvate is favoured.
17