Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors

TL;DR: Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture and are regions of signal transduction that relate to growth control.

TL;DR: It was necessary to fulfill all four conditions, i.e., integrin aggregation, integrin occupancy, tyrosine kinase activity, and actin cytoskeletal integrity, to achieve integrin- mediated focal accumulation of other cytoskeleton molecules including F- actin and paxillin.

TL;DR: In this paper, the authors discuss mechanisms of glioma invasion, characteristics of the invasive cell, and consequences of this cellular phenotype for surgical resection, oncologic treatments, and future perspectives for anti-invasive strategies.

TL;DR: This work has shown that vascular damage triggers reparative processes, such as hemostasis, inflammation, and wound healing, which depend on a coordinated series of cell growth, differentiation, survival, and function.

TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.

TL;DR: GF 109203X was a competitive inhibitor with respect to ATP and displayed high selectivity for PKC as compared to five different protein kinases, illustrating the potential of this compound as a tool for studying the involvement of PKC in signal transduction pathways.

TL;DR: The isolation of a cDNA encoding a protein, pp125, that is a major phosphotyrosine-containing protein in untransformed chicken embryo cells and exhibits an increase in phosphotYrosine in pp60v-src-transformedChicken embryo cells is reported.

TL;DR: A role for integrin- mediated tyrosine phosphorylation in the organization of the cytoskeleton as cells adhere to the extracellular matrix is suggested.