Type-I Angiotensin II Receptor Blockade Reduces Uremia-induced Deterioration of Bone Material Properties
Takuya Wakamatsu,Yoshiko Iwasaki,Suguru Yamamoto,Koji Matsuo,Shin Goto,Ichiei Narita,Junichiro James Kazama,Kennichi Tanaka,Akemi Ito,Ryosuke Ozasa,Takayoshi Nakano,Chisato Miyakoshi,Yoshihiro Onishi,Shingo Fukuma,Shunichi Fukuhara,Hideyuki Yamato,Masafumi Fukagawa,Tadao Akizawa +17 more
TL;DR: Angiotensin II‐dependent intraskeletal oxidation stress deteriorated the bone elastic mechanical properties by promoting osteocyte apoptosis and pentosidine accumulation in CKD and contributes to the underlying pathogenesis of abnormal bone quality in the setting of CKD.
read more
Abstract: Chronic kidney disease (CKD) is associated with a high incidence of fractures. However, the pathophysiology of this disease is not fully understood, and limited therapeutic interventions are available. This study aimed to determine the impact of type 1 angiotensin II receptor blockade (AT-1RB) on preventing CKD-related fragility fractures and elucidate its pharmacological mechanisms. AT-1RB use was associated with a lower risk of hospitalization due to fractures in 3276 patients undergoing maintenance hemodialysis. In nephrectomized rats, administration of olmesartan suppressed osteocyte apoptosis, skeletal pentosidine accumulation, and apatite disorientation, and partially inhibited the progression of the bone elastic mechanical properties, while the bone mass was unchanged. Olmesartan suppressed angiotensin II-dependent oxidation stress and apoptosis in primary cultured osteocytes in vitro. In conclusion, angiotensin II-dependent intraskeletal oxidation stress deteriorated the bone elastic mechanical properties by promoting osteocyte apoptosis and pentosidine accumulation. Thus, AT-1RB contributes to the underlying pathogenesis of abnormal bone quality in the setting of CKD, possibly by oxidative stress. © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis.
Ryosuke Ozasa,Aira Matsugaki,Takuya Ishimoto,Satoshi Kamura,Hiroto Yoshida,Mayu Magi,Yoshihiro Matsumoto,Koji Sakuraba,Kenjiro Fujimura,Hisaaki Miyahara,Takayoshi Nakano +10 more
TL;DR: In this paper, the authors focused on the bone matrix micro-arrangement, based on the preferential orientation of collagen and the related apatite c-axis as a bone quality index.
14
Combination treatment with ibandronate and eldecalcitol prevents osteoporotic bone loss and deterioration of bone quality characterized by nano-arrangement of the collagen/apatite in an ovariectomized aged rat model
Ryosuke Ozasa,Mitsuru Saito,Takuya Ishimoto,Aira Matsugaki,Yoshihiro Matsumoto,Takayoshi Nakano +5 more
TL;DR: In this article , the effects of ibandronate (IBN), eldecalcitol (ELD), and their combination on the collagen/apatite orientation and trabecular architectural anisotropy using an estrogen-deficiency-induced osteoporotic rat model were analyzed.
9
Study on Nursing Effect of Psychological Intervention on Uremic Hemodialysis Patients
TL;DR: The implementation of psychological nursing intervention for uremic hemodialysis patients have a very significant effect on reducing the incidence of complications and improving anxiety, depression, treatment compliance, and the quality of life and the nursing satisfaction.
Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis
TL;DR: Zhang et al. as mentioned in this paper examined periarticular proximal tibiae from RA patients as compared with osteoarthritis (OA) patients as controls to determine factors contributing to bone dysfunction in RA by focusing on the bone matrix micro-arrangement, based on the preferential orientation of collagen and the related apatite c-axis.
7
Superior Alignment of Human iPSC-Osteoblasts Associated with Focal Adhesion Formation Stimulated by Oriented Collagen Scaffold.
TL;DR: In this article, the superior cell adhesion behavior of human-induced pluripotent stem cells (hiPSC-Obs) associated with the promotion of FA assembly along an anisotropic scaffold was investigated.
6
References
Osteoporosis prevention, diagnosis, and therapy
Anne Klibanski,Lucile L. Adams-Campbell,Tamsen Bassford,Steven N. Blair,Scott D. Boden,Kay Dickersin,David R. Gifford,Lou Glasse,Steven R. Goldring,Keith A. Hruska,Susan R. Johnson,Laurie K. McCauley,William E. Russell +12 more
TL;DR: Though prevalent in white postmenopausal women, osteoporosis occurs in all populations and at all ages and has significant physical, psychosocial, and financial consequences.
5.4K
Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
A. Michael Parfitt,Marc K. Drezner,Francis H. Glorieux,John A. Kanis,Hartmut H. Malluche,Pierre J. Meunier,Susan M. Ott,Robert R. Recker +7 more
TL;DR: A committee of the Society to develop a unified system of termnology, suitable for adoption by the Journal of Bone and Mineral Research as part of its Instructions to Authors is formed, and is as complex and conceptually difficult as the field with which it deals.
5.4K
Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee
David W. Dempster,Juliet E. Compston,Marc K. Drezner,Francis H. Glorieux,John A. Kanis,Hartmut H. Malluche,Pierre J. Meunier,Susan M. Ott,Robert R. Recker,A. Michael Parfitt +9 more
TL;DR: The key revisions include omission of terminology used before 1987, recommendations regarding the parameters and technical information that should be included in all histomorphometry articles, recommendations on how to handle dynamic parameters of bone formation in settings of low bone turnover, and updating of references.
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
TL;DR: It is shown that renin expression and plasma angiotensin II production were increased severalfold in vitamin D receptor-null (VDR-null) mice, leading to hypertension, cardiac hypertrophy, and increased water intake, and 1,25(OH)(2)D(3) is a novel negative endocrine regulator of the renin-angiotens in system.
Increased risk of hip fracture among patients with end-stage renal disease
Astier M. Alem,Donald J. Sherrard,Daniel L. Gillen,Noel S. Weiss,Shirley A.A. Beresford,Susan R. Heckbert,Craig S. Wong,Catherine Stehman-Breen +7 more
TL;DR: The overall risk of hip fracture among Caucasian patients with ESRD is considerably higher than in the general population, independent of age and gender.
854