Tuning microenvironments: induction of regulatory T cells by dendritic cells.
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TL;DR: This review will discuss some new findings associating DCs from defined compartments with the induction of antigen-specific Treg cells in various populations of dendritic cells.
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About: This article is published in Immunity. The article was published on 19 Sep 2008. and is currently open access. The article focuses on the topics: Follicular dendritic cells & Antigen presentation.
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Citations
Regulatory T Cells: Mechanisms of Differentiation and Function
TL;DR: Cellular and molecular mechanisms in the differentiation and function of regulatory T cells and their role in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation are discussed.
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Control of regulatory T cell lineage commitment and maintenance.
TL;DR: This review discusses Treg cell differentiation and maintenance with a particular emphasis on molecular regulation of Foxp3 expression, arguably a key to mechanistic understanding of biology of regulatory T cells.
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Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance
TL;DR: It is speculated that the different origin of iTreg cells (noninflammatory versus inflammatory) results in distinct properties, including their stability, which could contribute to their stability in the context of immunological tolerance.
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Hypoxia-inducible factor-1 alpha–dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
Eric T. Clambey,Eóin N. McNamee,Joseph A. Westrich,Louise E. Glover,Eric L. Campbell,Paul Jedlicka,Edwin F. de Zoeten,John C. Cambier,Kurt R. Stenmark,Sean P. Colgan,Holger K. Eltzschig +10 more
TL;DR: It is demonstrated that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability.
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