Journal Article10.1088/1758-5090/AAFEC8
Tuning mechanical reinforcement and bioactivity of 3D printed ternary nanocomposites by interfacial peptide-polymer conjugates.
Onur Bas,Felix Hanßke,Jing Lim,Akhilandeshwari Ravichandran,Akhilandeshwari Ravichandran,Erhard Kemnitz,Swee Hin Teoh,Dietmar W. Hutmacher,Hans G. Börner +8 more
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TL;DR: It is demonstrated that the concept of bioinspired interface engineering facilitates the development of homogeneous ternary nanocomposites with increased processability in additive biomanufacturing, and leads to scaffolds exhibiting enhanced mechanical and biological properties.
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Abstract: We present a study on ternary nanocomposites consisting of medical grade poly(e-caprolactone) (mPCL) matrix, hydroxyapatite nanopowder (nHA) and compatibilized magnesium fluoride nanoparticle (cMgF2) fillers. MgF2 nanoparticles were compatibilized by following a design approach based on the material interfaces of natural bone. MgF2-specific peptide-poly(ethylene glycol) conjugates were synthesized and used as surface modifiers for MgF2 nanoparticles similarly to the non-collagenous proteins (NPC) of bone which compatibilize hydroxyapatite nanocrystallites. Different compositions of mPCL/nHA/cMgF2 composites were blended together and processed into three dimensional (3D) scaffolds using solvent-free techniques including cryomilling and melt extrusion-based additive manufacturing. The use of two different inorganic fillers in mPCL resulted in nanocomposite materials with enhanced mechanical and biological properties. In particular, cMgF2 nanoparticles were found to be the primary constitent leading to the significant improvements in the mechanical properties of these composites. The scaffolds of the ternary nanocomposites provided the best in vitro performance in terms of osteogenic differentiation and stimulated mineralization. In summary, we demonstrated that the concept of bioinspired interface engineering facilitates the development of homogeneous ternary nanocomposites with increased processability in additive biomanufacturing. Additionally, the concept leads to scaffolds exhibiting enhanced mechanical and biological properties. Overall, these multicomponent nano-interfaced building blocks add a new group of advanced functional materials with tunable mechanical properties, degradation and bioactivity.
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Citations
The return of a forgotten polymer : Polycaprolactone in the 21st century
Maria A. Woodruff,Dietmar W. Hutmacher +1 more
- 01 Apr 2010
TL;DR: Polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices for up to 3-4 years as discussed by the authors.
2.1K
Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges
Alina Ghilan,Aurica P. Chiriac,Loredana E. Nita,Alina Gabriela Rusu,Iordana Neamtu,Vlad Mihai Chiriac +5 more
TL;DR: A basic understanding of the fundamentals of 3D/4D printing along with bioprinting processes is provided and a glimpse into the future possibilities and benefits provided by machine learning in the additive manufacturing field is emphasized.
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The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering.
TL;DR: Polycaprolactone (PCL) has been widely used in the fabrication of 3D scaffolds in the field of bone tissue engineering due to its advantages such as good biocompatibility, slow degradation rate, the less acidic breakdown products in comparison to other polyesters, and the potential for loadbearing applications as discussed by the authors.
Synthesis and characterization of Co-Al mixed oxide nanoparticles via thermal decomposition route of layered double hydroxide
Mohamed Helmy Abdel-Aziz,Mohamed Helmy Abdel-Aziz,M. Sh. Zoromba,M. Sh. Zoromba,Mohamed Bassyouni,Mohamed Bassyouni,Mohammed Zwawi,Abdullah Alshehri,Ahmed F. Al-Hossainy +8 more
TL;DR: In this paper, mixed cobalt-aluminum layered double hydroxide (Co-Al LDH) is synthesized in the presence of functional amino-organic compounds, including glycine, acetamide and urea.
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Cryomilling as environmentally friendly synthesis route to prepare nanomaterials
TL;DR: The milling of materials at cryogenic temperature has gained importance both in academic as well as industrial community in the last two decades, primarily because of distinct advantages of different advantages as discussed by the authors.
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