Journal Article10.1016/S1076-6332(03)80279-9
Tumor microvascular changes to anti-angiogenic treatment assessed by MR contrast media of different molecular weights.
Timothy P.L. Roberts,K Turetschek,Anda Preda,Viktor Novikov,M Moeglich,David M. Shames,Robert C. Brasch,Hanns Joachim Weinmann +7 more
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About: This article is published in Academic Radiology. The article was published on 01 Feb 2002.
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MRI for assessing antivascular cancer treatments.
TL;DR: DCE-MRI studies can define the biologically active dose and predict the efficacy of treatment on the basis of changes observed, and intrinsic susceptibility-weighted MRI, which is sensitive to blood oxygenation and flow, is emerging as a technique that may be able to monitor vascular targeting therapies.
152
Dynamic Contrast-Enhanced and Diffusion MRI Show Rapid and Dramatic Changes in Tumor Microenvironment in Response to Inhibition of HIF-1α Using PX-478
Bénédicte F. Jordan,Bénédicte F. Jordan,Matthew L. Runquist,Natarajan Raghunand,Amanda F. Baker,Ryan Williams,Lynn Kirkpatrick,Garth Powis,Robert J. Gillies +8 more
TL;DR: PX-478 induced a dramatic reduction in tumor blood vessel permeability within 2 hours after treatment, which returned to baseline by 48 hours, which is the earliest significant response of ADC to therapy yet reported.
144
Dynamic contrast-enhanced MR imaging kinetic parameters and molecular weight of dendritic contrast agents in tumor angiogenesis in mice.
Quido G. de Lussanet,Sander Langereis,Regina G. H. Beets-Tan,Marcel H. P. van Genderen,Arjan W. Griffioen,Jos M. A. van Engelshoven,Walter H. Backes +6 more
TL;DR: Macromolecular permeability is best measured with high-molecular-weight contrast agents; endothelial K(PS) values measured with low-molescular- Weight contrast agents incorporate tissue perfusion and permeability and demonstrate heterogeneous microcirculatory flow.
112
Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth.
Khuloud T. Al-Jamal,Wafa' T Al-Jamal,Simon Akerman,Jennifer E Podesta,Açelya Yilmazer,John Turton,Alberto Bianco,Neil Vargesson,Chryso Kanthou,Alexander T. Florence,Gillian M. Tozer,Kostas Kostarelos +11 more
TL;DR: It is suggested that PLL-dendrimer molecules can exhibit a systemic antiangiogenic activity that may be used for therapy of solid tumors, and in combination with their capacity to carry other therapeutic or diagnostic agents may potentially offer capabilities for the design of theranostic systems.
Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma.
Pasquina Marzola,Anna Degrassi,Laura Calderan,Paolo Farace,Elena Nicolato,Caterina Crescimanno,Marco Sandri,Anna Maria Giusti,Enrico Pesenti,Andrea Terron,Andrea Sbarbati,Francesco Osculati +11 more
TL;DR: The early antiangiogenic activity of SU11248 was detected in vivo by DCE-MRI techniques using either macromolecular or low molecular weight contrast agents, which could be relevant for the design of clinical trials based on new paradigms.
98
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Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade.
TL;DR: This relatively simple method of analysis provides quantitative estimates of fBV and microvascular permeability in human brain tumors, with the permeability being predictive of pathologic grade.
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Prostate Cancer Tumor Grade Differentiation with Dynamic Contrast-enhanced MR Imaging in the Rat: Comparison of Macromolecular and Small-Molecular Contrast Media—Preliminary Experience
Axel Gossmann,Yoshitaka Okuhata,David M. Shames,Thomas H. Helbich,Timothy P.L. Roberts,Michael F. Wendland,Sabine Huber,Robert C. Brasch +7 more
TL;DR: Quantitative microvascular permeability characteristics estimated from macromolecularCM-enhanced data were significantly superior to those derived from small-molecular CM-enhancing data, allowing differentiation of histopathologic prostatic tumor types.
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Breast cancer angiogenesis--new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting.
Adrian L. Harris,Hua-Tang Zhang,Amir Moghaddam,Steve Fox,Prudence A. E. Scott,Adam Pattison,Kevin C. Gatter,Ian J. Stratford,Roy Bicknell +8 more
TL;DR: The endpoint of stable disease and biochemical assessment of inhibition of angiogenesis may be much more important in therapeutic studies and for drug development in the future, because inhibition of new blood vessel formation may not cause tumour regression.
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Quantitative Estimation of Microvascular Permeability in Human Brain Tumors
TL;DR: The aim of this study was to implement a technique that can be used to quantify fBV as well as the microvascular permeability in patients with brain tumors and to assess whether permeability quantifications improve the noninvasive assessment of tumor malignancy.
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Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology
Karl Turetschek,Eugenia Floyd,David M. Shames,Timothy P.L. Roberts,Anda Preda,Viktor Novikov,Claire Corot,Wayne O. Carter,Robert C. Brasch +8 more
TL;DR: It is suggested that contrast media of relatively large (on the order of 90 kDa) molecular size, such as albumin‐(GdDTPA)30, are more accurate for the characterization of tumor microvessels.
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