Triggered Release from Thermosensitive Liposomes Improves Tumor Targeting of Vinorelbine
Maximilian Regenold,Kan Kaneko,Xuehan Wang,H Benson Peng,James Evans,Pauric Bannigan,Christine Allen +6 more
TL;DR: In this article , the authors explored the therapeutic potential of a thermosensitive liposome formulation of the commonly used chemotherapy drug vinorelbine in combination with mild hyperthermia (39-43 °C) in a murine model of rhabdomyosarcoma.
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Abstract: Triggered drug delivery strategies have been shown to enhance drug accumulation at target diseased sites in comparison to administration of free drug. In particular, many studies have demonstrated improved targetability of chemotherapeutics when delivered via thermosensitive liposomes. However, most studies continue to focus on encapsulating doxorubicin while many other drugs would benefit from this targeted and localized delivery approach. The proposed study explores the therapeutic potential of a thermosensitive liposome formulation of the commonly used chemotherapy drug vinorelbine in combination with mild hyperthermia (39-43 °C) in a murine model of rhabdomyosarcoma. Rhabdomyosarcoma, the most common soft tissue sarcoma in children, is largely treated using conventional chemotherapy which is associated with significant adverse long-term sequelae. In this study, mild hyperthermia was pursued as a non-invasive, non-toxic means to improve the efficacy and safety profiles of vinorelbine. Thorough assessment of the pharmacokinetics, biodistribution, efficacy and toxicity of vinorelbine administered in the thermosensitive liposome formulation was compared to administration in a traditional, non-thermosensitive liposome formulation. This study shows the potential of an advanced formulation technology in combination with mild hyperthermia as a means to target an untargeted therapeutic agent and result in a significant improvement in its therapeutic index. Graphical abstract
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The development of electrochemical DNA biosensor based on woolen ball-shaped La3+/TiO2 nanostructure coating: Nanomolar detection of Vinorelbine
Mohammad Mehdi Foroughi,Shohreh Jahani,Soroush Rashidi,Omid Tayari,Mehran Moradalizadeh +4 more
TL;DR: A novel electrochemical DNA biosensor based on La3+/TiO2 nanostructure coating is developed for nanomolar detection of Vinorelbine, a powerful anticancer medication, with a detection limit of 0.37 nM and linear range of 0.001-150.0 μM.
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Harnessing immunotherapy to enhance the systemic anti-tumor effects of thermosensitive liposomes
TL;DR: In this article , the authors explored the systemic treatment capabilities of a thermosensitive liposome formulation of the vinca alkaloid vinorelbine in combination with mild hyperthermia in an immunocompetent murine model of rhabdomyosarcoma.
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