Trial sequential analysis: plain and simple

TL;DR: In this paper, a meta-analysis was conducted to investigate dexmedetomidine efficacy in attenuating sympathetic response to tracheal intubation, compared with placebo or no dexmedetermidine, in terms of heart rate and blood pressure.

TL;DR: In this article , a systematic review and meta-analysis aimed to investigate the clinical efficacy and safety of systemic corticosteroids in the treatment of patients with severe community-acquired pneumonia (sCAP).

TL;DR: OVP appears to be an efficacious option for prevention of CDI in high-risk subjects undergoing SAT, Nevertheless, additional data from RCTs are needed to establish OVP as good clinical practice and define optimal dosage and duration.

TL;DR: A recent landmark randomized controlled trial (RCT) in septic patients demonstrated an increased risk of death and persistent organ dysfunction with intravenous Vitamin C (IVVC) monotherapy, which represents a disparate result from previous systematic reviews and meta-analyses as discussed by the authors .

TL;DR: Trial Sequential Analysis represents analysis of meta-analytic data, with transparent assumptions, and better control of type I and type II errors than the traditional meta-analysis using naïve unadjusted confidence intervals.

TL;DR: D2 seems a better alternative than I2 to consider model variation in any random-effects meta-analysis despite the choice of the between trial variance estimator that constitutes the model.

TL;DR: The alpha spending function approach is reviewed, and its applicability to a variety of commonly used statistical procedures, including survival and longitudinal methods are detailed.