What were the main criteria used for the assessment of each study?

The items used for the assessment of each study were the following: adequacy of random sequence generation, allocation concealment, blinding of participants, personnel and outcome assessment, handling of drop-outs (incomplete outcome data), selective outcome reporting, and other potential sources of bias.

What methods were used to adjust the analysis for publication bias?

Duval & Tweedie ‘trim and fill’ and ‘fail-safe N’ methods were used to adjust the analysis for the effects of publication bias[19].

What is the effect of adiponectin on diabetes?

It hypothesized, adiponectin with its antagonistic effects on TNF-a, may improve diabetes, hypertension, apoptosis, and atherosclerosis [35].

What is the role of adiponectin in diabetes?

Adiponectin is another inflammatory marker, derived from adipose tissue that has been shown to be involved in the obesity and T2DM complicated by cardiovascular diseases.

What is the main reason for the study?

the majority of the studies finally included in the analysis had relatively small sample sizes, potentially leading to publication bias and overestimation of treatment effects, because smaller trials might be methodologically less robust and are prone to report larger effect sizes[37, 38].

What was the effect size of the funnel plot?

The funnel plot of standard error vs. effect size (mean difference) was asymmetric and suggested potential publication bias, fig4.

What is the effect of chronic treatment of GLP-1 agonists on inflammatory markers?

little is known about the effects of chronic treatment with GLP-1 receptor agonist on inflammatory markers that are known to be associated with obesity or type 2 diabetes.

Open AccessJournal Article10.1016/J.JDIACOMP.2016.05.022

Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

Q: What method was used to evaluate the association between the WMD and potential moderator?

Random effects meta-regression was performed using the unrestricted maximum likelihood method to evaluate the association between calculated WMD and potential moderator, duration of treatment with GLP-1 RAs.

Q: What are the contributions in "Treatment with glp1 receptor agonists reduce serum crp concentrations in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials" ?

In this paper, the effect of GLP-1 RAs on serum CRP was evaluated by systematically reviewing the existing randomize control trials.

Q: What is the role of GLP-1 in the regulation of blood glucose?

GLP-1 can suppress appetite, food intake, decelerate gastric emptying and induce satiety, so it plays an important role in the regulation of blood glucose [4, 5].

Q: Why was an r value assumed in this meta-analysis?

Because the pretest–posttest correlation coefficients (r) were not reported in studies, an r value of 0.5 was assumed through this meta-analysis, as this value was a conservative estimate for r which ranges between 0 and 1 [18].

Mohsen Mazidi, +3 more

- 01 Jul 2017

- Journal of Diabetes and Its Complication...

- Vol. 31, Iss: 7, pp 1237-1242

TL;DR: This meta-analysis suggests that GLP-1 RAs therapy causes a significant reduction in CRP, and was associated with the duration of treatment.

Abstract: Aim: To undertake a systematic review and meta-analysis of randomized controlled trials of the effect of Glucagon-like peptide-1 receptor agonist (GLP-1 RAs) therapy on serum C-reactive protein (CRP) concentrations. Method: PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched for the period up until March 16 2016. Prospective studies evaluating the impact of GLP-1 RAs on serum CRP were identified. A random effects model (using the DerSimonian-Laird method) and generic inverse variance methods were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Heterogeneity was quantitatively assessed using the I2 index. Random effects meta-regression was performed using unrestricted maximum likelihood method to evaluate the impact of potential moderator. International Prospective Register for Systematic Reviews (PROSPERO) number CRD42016036868. Results: Meta-analysis of the data from 7 treatment arms revealed a significant reduction in serum CRP concentrations following treatment with GLP-1 RAs (WMD –2.14 (mg/dL), 95% CI -3.51, –0.78, P=0.002; I2 96.1%). Removal of one study in the meta-analysis did not change the result in the sensitivity analysis (WMD –2.14(mg/dL), 95% CI -3.51, –0.78, P=0.002; I2 96.1%), indicating that our results could not be solely attributed to the effect of a single study. Random effects meta-regression was performed to evaluate the impact of potential moderator on the estimated effect size. Changes in serum CRP concentration were associated with the duration of treatment (slope –0.097, 95% CI –0.158, -0.042, P<0.001). Conclusions: This meta-analysis suggests that GLP-1 RAs therapy causes a significant reduction in CRP.

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Most frequently asked questions

1. What method was used to evaluate the association between the WMD and potential moderator?

Random effects meta-regression was performed using the unrestricted maximum likelihood method to evaluate the association between calculated WMD and potential moderator, duration of treatment with GLP-1 RAs.

2. What are the contributions in "Treatment with glp1 receptor agonists reduce serum crp concentrations in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials" ?

In this paper, the effect of GLP-1 RAs on serum CRP was evaluated by systematically reviewing the existing randomize control trials.

3. What is the role of GLP-1 in the regulation of blood glucose?

GLP-1 can suppress appetite, food intake, decelerate gastric emptying and induce satiety, so it plays an important role in the regulation of blood glucose [4, 5].

4. Why was an r value assumed in this meta-analysis?

Because the pretest–posttest correlation coefficients (r) were not reported in studies, an r value of 0.5 was assumed through this meta-analysis, as this value was a conservative estimate for r which ranges between 0 and 1 [18].

- Controlled Clinical Trials

TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.

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Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

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AI Agents for this Paper

Most frequently asked questions

1. What method was used to evaluate the association between the WMD and potential moderator?

2. What are the contributions in "Treatment with glp1 receptor agonists reduce serum crp concentrations in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials" ?

3. What is the role of GLP-1 in the regulation of blood glucose?

4. Why was an r value assumed in this meta-analysis?

5. What were the main criteria used for the assessment of each study?

6. What methods were used to adjust the analysis for publication bias?

7. What is the effect of adiponectin on diabetes?

8. What is the role of adiponectin in diabetes?

9. What is the main reason for the study?

10. What was the effect of exenatide on the CRP?

11. What was the effect size of the funnel plot?

12. What is the effect of chronic treatment of GLP-1 agonists on inflammatory markers?

Figures

Citations

COVID-19 in people with diabetes: understanding the reasons for worse outcomes.

Effect of Sodium-Glucose Cotransport-2 Inhibitors on Blood Pressure in People With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of 43 Randomized Control Trials With 22 528 Patients.

Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus.

The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients: A Meta-Analysis.

Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence.

References

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

Assessing the quality of reports of randomized clinical trials : is blinding necessary?

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Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.