Journal Article10.1016/J.VETIMM.2014.12.001
Transcriptome changes upon in vitro challenge with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and healthy cows
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TL;DR: For macrophages, kallikrein-related peptidase 12 (KLK12) and protease, serine, 2 (trypsin 2) (PRSS2), as well as a secreted protein, acidic, cysteine-rich (SPARC)-centered matricellular gene network, were differentially expressed in infected animals.
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About: This article is published in Veterinary Immunology and Immunopathology. The article was published on 15 Feb 2015. The article focuses on the topics: Multiplicity of infection & Chemokine.
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Citations
Detection of latent forms of Mycobacterium avium subsp. paratuberculosis infection using host biomarker-based ELISAs greatly improves paratuberculosis diagnostic sensitivity.
Cristina Blanco Vázquez,Marta Alonso-Hearn,Ramón A. Juste,Maria Canive,Tania Iglesias,Natalia Iglesias,Javier Amado,Fernando Vicente,Ana Balseiro,Rosa Casais +9 more
TL;DR: It is suggested that quantification of ABCA13, SPARC and MMP8 by ELISA has the potential for implementation as a diagnostic tool to reliably identify MAP infection, greatly improving early detection of MAP latent infections when antibody responses and fecal shedding are undetectable using conventional diagnostic methods.
Johne's disease in cattle: an in vitro model to study early response to infection of Mycobacterium avium subsp. paratuberculosis using RNA-seq.
Rosanna Marino,Rosanna Marino,Rossana Capoferri,Simona Panelli,Giulietta Minozzi,Francesco Strozzi,Erminio Trevisi,Gustavo Geraldo Medina Snel,Paolo Ajmone-Marsan,John L. Williams +9 more
TL;DR: This study shows that MAP infection is associated with changes in expression of genes related to the host immune response that may affect its ability to survive and multiply inside the host cell.
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Differential gene expression in Mycobacterium bovis challenged monocyte-derived macrophages of cattle.
Sanjeev Kumar Shukla,Shubhra Shukla,Anuj Chauhan,Sarvjeet,Rehan Khan,Anuj Ahuja,Lakshya Veer Singh,Naveen Sharma,Chandan Prakash,Ajay Vir Singh,Manjit Panigrahi +10 more
TL;DR: The pattern of expression of these genes in PPD bovine stimulated PBMC provides the first description of an M. bovis specific signature of infection that may provide insights into the molecular basis of the host response to infection.
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Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
Naveed Sabir,Tariq Hussain,Yi Liao,Jie Wang,Yinjuan Song,Muhammad Shahid,Guangyu Cheng,Mazhar Hussain Mangi,Jiao Yao,Lifeng Yang,Deming Zhao,Xiangmei Zhou +11 more
TL;DR: Findings suggest that upregulation of KLK12 in M. bovis infected murine macrophages plays a substantial role in the protective immune response regulation by modulating autophagy, apoptosis and pro-inflammatory pathways.
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Sp110 enhances macrophage resistance to Mycobacterium tuberculosis via inducing endoplasmic reticulum stress and inhibiting anti-apoptotic factors
TL;DR: The mechanism of Sp110 enhanced macrophage apoptosis in response to Mtb infection is revealed, and new insights are provided into the study of host-pathogen interactions.
References
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.
1.5K
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TL;DR: NOS2(-/-) mice proved highly susceptible, resembling wild-type littermates immunosuppressed by high-dose glucocorticoids, and allowed Mycobacterium tuberculosis to replicate faster in the lungs than reported for other gene-deficient hosts.
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TL;DR: To improve current vaccine strategies, it is necessary to understand the factors that mediate induction, expression, and regulation of the immune response in the lung and determine how to induce both known and novel immunoprotective responses without inducing immunopathologic consequences.
Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.
TL;DR: The prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.
861
Endothelin System: The Double-Edged Sword in Health and Disease
TL;DR: The endothelin system consists of two G-protein-coupled receptors, three peptide ligands, and two activating peptidases, which have a variety of physiological and pathophysiological roles in the vessels and brain.
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