Transcription: the epicenter of gene expression
TL;DR: The latest advances in epigenetics, mRNA processing, RNA quality control, and human immunodeficiency virus (HIV) transactivation are discussed.
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Abstract: The complexity of a living organism is not driven by gene number but gene regulation. Controlling which genes to express and to what extent dictates the subsequent cell identity. Transcription, the critical initial stage in gene expression, is regulated delicately to maintain the cell status. Recent developments in the genomic approaches provided unparalleled coverage of the study of transcription. Still, basic molecular biology and biochemistry are providing mechanistic insights into how the regulation is achieved. In this feature “Regulation of transcription: mechanisms and biological functions”, the latest advances in epigenetics, mRNA processing, RNA quality control, and human immunodeficiency virus (HIV) transactivation are discussed.
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Citations
Accentuating CircRNA-miRNA-Transcription Factors Axis: A Conundrum in Cancer Research
TL;DR: The regulatory function of the circRNA-miRNA-TFs axis in the progression or suppression of cancer and the targeting of this axis as a potential therapeutic approach for cancer management are highlighted.
32
Circular RNAs and Neuronal Development.
TL;DR: This book chapter will review research progress into the function of circRNAs during neuronal development, with the major themes to be discussed are the enrichment of circ RNAs in the synapse and their possible contributions to synaptopathologies, in addition to the findings that neuralcircRNAs accumulate with age and appear beneficial for neuronal repair.
21
Nuclear architecture and the structural basis of mitotic memory
TL;DR: A hypothesis is proposed that a subset of NuMat proteome essential for nucleation of various nuclear bodies are retained in MiCS to serve as seeds of mitotic memory, thus ensuring the daughter cells re-establish the complex status of nuclear architecture similar to that of the mother cells, thereby maintaining the pre-mitotic transcriptional status.
6
Trends and Applications of Omics Technologies to Functional Characterisation of Enzymes and Protein Metabolites Produced by Fungi.
TL;DR: A detailed overview of the necessary steps employed in both qualitative and quantitative research using the omics technologies that are pertinent to fungi characterisation is provided in this paper, where the functional gaps left by genomics, internal transcribe spacer (ITS) regions are addressed by transcriptomics and various techniques and platforms utilised, including quantitive reverse transcription polymerase chain reaction (RT-qPCR), hybridization techniques, and RNA-seq, and the insights such data provide on the effect of environmental changes on fungal enzyme production from an expressional standpoint.
5
•Dissertation
Functional characterisation of constitutive expresser of pathogenesis-related genes 5 : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Molecular Biology at Massey University, Palmerston North, New Zealand
Muhammad Faisal
- 01 Jan 2017
TL;DR: CPR5 as a master regulatorreview of literature concludes with a list of recommended practices and recommendations for further study.
2
References
Central Dogma of Molecular Biology
TL;DR: The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information and states that such information cannot be transferred from protein to either protein or nucleic acid.
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells.
TL;DR: In this paper, alternative cleavage and polyadenylation (APA) was shown to have functional consequences with shorter mRNA isoforms exhibiting increased stability and typically producing ten-fold more protein, in part through the loss of microRNA-mediated repression.
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Transcriptional Regulation and Its Misregulation in Disease
Tong Ihn Lee,Richard A. Young +1 more
TL;DR: Recent advances in understanding of transcriptional regulation are reviewed and how these have provided new insights into transcriptional misregulation in disease are discussed.
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Control of the Embryonic Stem Cell State
TL;DR: This work has provided insights into the transcriptional control of embryonic stem cell state, including the regulatory circuitry underlying pluripotency and uncovered fundamental mechanisms that control mammalian gene expression, connect gene expression to chromosome structure, and contribute to human disease.
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