Open AccessJournal Article10.1038/S41582-020-00421-4

Towards treating progressive multiple sclerosis.

- 06 Oct 2020

- Vol. 16, Iss: 11, pp 589-590

TL;DR: Following extensive progress in the treatment of relapsing multiple sclerosis, the major challenge in the field is now to develop effective therapies for progressive forms of multiple sclerosis.

Abstract: Following extensive progress in the treatment of relapsing multiple sclerosis, the major challenge in the field is now to develop effective therapies for progressive forms of multiple sclerosis. As the first signs of success emerge, now is the time to consider the research needed to move the field forward.

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1. What are the contributions in "Nature reviews neurology -- neurology at the crossroads towards treating progressive multiple sclerosis" ?

However, the challenge of understanding the mechanisms underpinning progression remains, and until the authors really understand what progression actually means, they will struggle to develop truly effective treatments this paper.

Citations

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Positron emission tomography in multiple sclerosis - straight to the target.

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Towards treating progressive multiple sclerosis.

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AI Agents for this Paper

Most frequently asked questions

1. What are the contributions in "Nature reviews neurology -- neurology at the crossroads towards treating progressive multiple sclerosis" ?

Citations

Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting

The role of glial cells in multiple sclerosis disease progression

Positron emission tomography in multiple sclerosis - straight to the target.

PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation.

Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain

References

MAFG-driven astrocytes promote CNS inflammation.

Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

Progression of regional grey matter atrophy in multiple sclerosis.

Mechanisms underlying progression in multiple sclerosis.

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART) : a phase 2b, multiarm, double-blind, randomised placebo-controlled trial