Open AccessJournal Article
Towards rational drug therapy in old age. The F.E. Williams Lecture 1985.
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TL;DR: The frequency of ADRs may have fallen over the last 20 years but, at their most recent absolute level, they leave no place for complacency, and they are still at least twice as worrying as they were in the 1990s.
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About: This article is published in Journal of The Royal College of Physicians of London. The article was published on 01 Oct 1985. and is currently open access.
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Citations
New Drugs: Prescribing in old age
TL;DR: The main areas of importance that have emerged from research into drugs in the elderly are outlined and the possible implications for future prescribing, drug research, and drug development will be discussed.
Age and Genetic Factors in Drug Interactions
James McElnay,P.F. Darcy +1 more
TL;DR: Age and genetic influences have been pinpointed as significant contributors to problems with drug therapy.
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Clinical trials in elderly subjects.
TL;DR: It is now generally recognized that age is a major source of variation in response to drugs in man, including changes in ratio of muscle to fat mass, hepatic extraction and metabolism, renal clearance, and regional blood flow.
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How much can elderly patients tell us about their medications
H. al Mahdy,D. G. Seymour +1 more
TL;DR: Out-patients were more knowledgeable about their medications than day hospital patients or inpatients, and their ability to recall their medications was superior to that of other patients.
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TL;DR: The decrease in creatinine clearance with age seen in this study represents true renal aging and is not secondary to diseases which become increasingly prevalent in the elderly.
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Digoxin Metabolism in the Elderly
TL;DR: The same dose of tritiated digoxin resulted in higher blood concentrations and longer blood half-life in the elderly, due to the smaller body size and a diminished urinary excretion of digoxin inThe elderly.
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Renal Tubular Secretion of Digoxin
TL;DR: After blocking the tubular secretion of digoxin, the calculated renal clearances of nonproteinbound digoxin in plasma were similar to that of inulin, suggesting a glomerular filtration of free plasma digoxin.
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Lignocaine kinetics in cardiac patients and aged subjects.
TL;DR: The 24 h urinary recovery of the major metabolite (total 4-hydroxyxylidine) showed a significant reduction in the elderly when compared to the young, and the clinical significance of these studies with respect to lignocaine therapy has been discussed.
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EFFECT OF THYROID FUNCTION ON NUMBER OF Na-K PUMPS IN HUMAN SKELETAL MUSCLE
TL;DR: The number of 3H-ouabain binding sites was measured in biopsy specimens from the vastus lateralis muscle of euthyroid subjects and patients with hypothyroidism or hyperthyroidism to evaluate the effect of thyroid function on the number of Na-K pumps in skeletal muscle.
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