Tissue engineering: challenges and selected application
Maksym Pogorielov,Oleks,r Oleshko,Andrii Hapchenko +3 more
- 07 Nov 2017
- Vol. 3, Iss: 2
TL;DR: Patient-derived cells can be expanded in culture and prompted to differentiate into a specific tissue or organ, followed by transplantation in a patient with no need of another patientmatching cell/tissue/organ donor.
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Abstract: Tissue engineering combines cells, biomaterials and growth factors to support and regenerate biological tissues. The key objective of tissue engineering is to improve quality of life in a secure way by avoiding various adverse effects of several standard medical therapies [2] and replace or repair damaged tissues by creating new healthy niches enabling cells to grow, proliferate and differentiate [3]. There are also multiple attempts to generate new tissues and even entire organs in vitro, ready to be implanted into the diseased and mechanically damaged sites. This involves e.g. the simulation or mimicry of the extracellular matrix (ECM) [4]. Thus, patient-derived cells can be expanded in culture and prompted to differentiate into a specific tissue or organ, followed by transplantation in a patient with no need of another patientmatching cell/tissue/organ donor.
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