Journal Article10.1007/S10517-010-0726-5
Time Course of Expression of “Early” Genes during Long-Term Posttetanic Potentiation in Rat Hippocampal CA1 Field
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TL;DR: The expression of egr-1, junB, c-jun, and c-fos genes in rat hippocampal CA1 fi eld was studied by the real-time PCR 30, 60, and 120 min after induction of long-term posttetanic potentiation.
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Abstract: The expression of egr-1, junB, c-jun, and c-fos genes in rat hippocampal CA1 fi eld was studied by the real-time PCR 30, 60, and 120 min after induction of long-term posttetanic potentiation. The content of egr-1, junB, and c-jun mRNA gradually increased and doubled 120 min after tetanization. The increase in c-jun mRNA level lagged behind the increment of egr-1 and junB. The level of c-fos mRNA increased 30 min after tetanization, returned to the initial level by min 60, and again increased 120 min after induction of long-term posttetanic potentiation.
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Long-Term Potentiation-Associated Gene Expression: Involvement of the Tumour Protein p53
P. D. Lisachev,Mark B. Shtark +1 more
- 11 Jul 2018
TL;DR: This chapter presents a short review of published articles devoted to the analysis of gene expression during LTP formation including studies of the mechanism of LTP-associated S100B upregulation in hippocampus.
Effects of Transcranial Direct Current Stimulation on Expression of Immediate Early Genes (IEG’s)
Jessica A Wagner
- 01 Dec 2015
TL;DR: Findings indicate that tDCS does affect neuronal activation by means of I EG induction and that there is dose dependence between current intensity used and mRNA levels of IEG's.
References
Transcription Factors in Long-Term Memory and Synaptic Plasticity
TL;DR: The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.
Direct evidence for biphasic cAMP responsive element-binding protein phosphorylation during long-term potentiation in the rat dentate gyrus in vivo.
TL;DR: The spatial and temporal dynamics of CREB phosphorylation during hippocampal LTP are resolved, showing that the transcription factor CREB is specifically recruited at two distinct time points in some forms of hippocampal synaptic plasticity in vivo.
158
Immediate-early genes, kindling and long-term potentiation
TL;DR: A class of genes called "immediate-early genes" that were previously thought to be only involved in cell division, differentiation and perhaps neoplasia have been shown to be rapidly and transiently induced in adult neurons following afterdischarges, ECS and chemically-evoked seizures.
154
Plasticity-specific phosphorylation of CaMKII, MAP-kinases and CREB during late-LTP in rat hippocampal slices in vitro
Tariq Ahmed,Julietta U. Frey +1 more
TL;DR: Results describing the regulation of alphaCaMKII, MAPKs and CREB phosphorylation during early stages of LTP are extended, suggesting a specific role of these enzymes also during phases ofLTP consolidation in adult animals.
120
Role of transcription factor AP-1 in integration of cell signaling systems
TL;DR: Transcription factor AP-1 is a dimer formed by DNA-binding proteins of the Jun, Fos, and ATF families (activating transcription factor) that mediates the cell response to growth factors, cytokines, neurotransmitters, and other intercellular signaling molecules.
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