Thymosin Beta-4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction.
Chester L. Drum,Warren K. Y. Tan,Warren K. Y. Tan,Siew Pang Chan,Siew Pang Chan,Siew Pang Chan,Leroy S. Pakkiri,Jenny P.C. Chong,Jenny P.C. Chong,Oi-Wah Liew,Oi-Wah Liew,Tze Pin Ng,Tze Pin Ng,Lieng-Hsi Ling,David Sim,Kui‐Toh G. Leong,Daniel P S Yeo,Hean Yee Ong,Hean Yee Ong,Fazlur Jaufeerally,Fazlur Jaufeerally,Raymond Wong,Ping Chai,Adrian F. Low,Pia Davidsson,Mathias Liljeblad,Ann-Sofi Söderling,Li-Ming Gan,Ratan Bhat,Kristy Purnamawati,Carolyn S.P. Lam,A. Mark Richards,A. Mark Richards,A. Mark Richards +33 more
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TL;DR: It is shown that plasma TB4 is elevated in women with HFpEF and has prognostic information, and the relation of endogenous, circulating TB4 to X chromosome biology and differential outcomes in female heart disease warrants further study.
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Abstract: BackgroundThymosin beta‐4 (TB4) is an X‐linked gene product with cardioprotective properties. Little is known about plasma concentration of TB4 in heart failure (HF), and its relationship with othe...
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Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning
Åsa K Hedman,Åsa K Hedman,Camilla Hage,Anil Sharma,M J Brosnan,Leonard Buckbinder,Li-Ming Gan,Sanjiv J. Shah,Cecilia Linde,Erwan Donal,Jean-Claude Daubert,Anders Mälarstig,Anders Mälarstig,Daniel Ziemek,Lars Lund +14 more
TL;DR: Using machine learning, six distinct HFpEF phenogroups with differential characteristics and outcomes are identified, as well as differential levels of inflammatory and cardiovascular proteins.
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Heart Failure in the Era of Precision Medicine: A Scientific Statement From the American Heart Association
Sharon Cresci,Naveen L. Pereira,Ferhaan Ahmad,Mirnela Byku,Lisa de las Fuentes,David E. Lanfear,Carolyn M. Reilly,Anjali T. Owens,Matthew J. Wolf +8 more
- 01 Oct 2019
TL;DR: The goals of this statement are to provide a comprehensive overview of the current state of these omics as they relate to the development and progression of heart failure and to consider the current and potential future applications of these data for precision medicine with respect to prevention, diagnosis, and therapy.
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Precision Medicine and the future of Cardiovascular Diseases: A Clinically Oriented Comprehensive Review
Yashendra Sethi,Neil Patel,N. M. Kaka,Oroshay Kaiwan,Jill Kar,Arsalan Moinuddin,Ashish Goel,Hitesh Chopra,Simona Cavalu +8 more
TL;DR: In this article , the authors present a review of the evolving clinically relevant tools of precision medicine that can help with the evidence-based precise individualized management of cardiac diseases with the highest DALY.
Cyclin dependent kinase inhibitor 1 C is a female-specific marker of left ventricular function after acute myocardial infarction
Torkia Lalem,Lu Zhang,Markus Scholz,Ralph Burkhardt,Victoria Saccheti,Andrej Teren,Joachim Thiery,Yvan Devaux +7 more
TL;DR: CDKN1C is a novel female-specific biomarker of LV function after AMI, and is a significant univariate predictor ofLV function in women only.
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Thymosin β4: A Multi-Faceted Tissue Repair Stimulating Protein in Heart Injury.
TL;DR: The present review highlights the promising role of Tβ4 in cardiac healing due to its activation of resident epicardial progenitor cells and modulation of inflammatory-caused injuries.
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