Three dimensional microstructural network of elastin, collagen, and cells in Achilles tendons

TL;DR: The aim of this review is to provide an overview of the role of non‐collagenous ECM proteins and less abundant collagens in tendon development and homeostasis.

TL;DR: It is demonstrated that interfibrillar load transfer is not supported by extrafibrillsar tissue components and support the hypothesis that collagen fibrils are capable of transmitting loads themselves.

TL;DR: Picrosirius red (PSR) staining, relying on the birefringence of collagen fibers, is one of the best understood histochemical methods that can highly and specifically underline fibers better than other common staining techniques when combined with polarized light microscopy.

TL;DR: The authors' biomimetic substrates combining biophysical and biological cues modulate stem cell behavior potentiating their long-term tenogenic commitment and the production of an elastin-rich ECM.

TL;DR: Preliminary evidence from invertebrates is included which suggests that the principles for bipolar fibril assembly were established at least 500 million years ago, and how mature fibrils are assembled from early fibrILS is reviewed.

TL;DR: The basic function of the tendon is to transmit the force created by the muscle to the bone, and, in this way, make joint movement possible, the complex macro‐ and microstructure of tendons and tendon fibers make this possible.

TL;DR: This work shows how its unique triple-helix structure and extremely high level of crystallinity make it exceptionally efficient in generating the second harmonic of incident light leads to a novel mode of microscopy of immediate practical significance in medicine and biology.

TL;DR: The purpose of the current review is to highlight the structure‐function relationship of tendons and related structures to provide an overview for readers whose interest in tendons needs to be underpinned by anatomy.