Three-dimensional Integrated Functional, Structural, and Computational Mapping to Define the Structural "Fingerprints" of Heart-Specific Atrial Fibrillation Drivers in Human Heart Ex Vivo.
Jichao Zhao,Brian J. Hansen,Yufeng Wang,Thomas A. Csepe,Lidiya V. Sul,Alan Tang,Yiming Yuan,Ning Li,Anna Bratasz,Kimerly A. Powell,Ahmet Kilic,Peter J. Mohler,Paul M.L. Janssen,Raul Weiss,Orlando P. Simonetti,John D. Hummel,Vadim V. Fedorov +16 more
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TL;DR: A novel 3D computational high‐resolution framework may be used to quantitatively analyze structural substrates, such as wall thickness, myofiber orientation, and fibrosis, underlying localized AF drivers, and aid the development of new patient‐specific treatments.
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Abstract: BackgroundStructural remodeling of human atria plays a key role in sustaining atrial fibrillation (AF), but insufficient quantitative analysis of human atrial structure impedes the treatment of AF....
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A global benchmark of algorithms for segmenting the left atrium from late gadolinium-enhanced cardiac magnetic resonance imaging.
Zhaohan Xiong,Qing Xia,Zhiqiang Hu,Ning Huang,Cheng Bian,Yefeng Zheng,Sulaiman Vesal,Nishant Ravikumar,Andreas Maier,Xin Yang,Pheng-Ann Heng,Dong Ni,Caizi Li,Qianqian Tong,Weixin Si,Elodie Puybareau,Younes Khoudli,Thierry Géraud,Chen Chen,Wenjia Bai,Daniel Rueckert,Lingchao Xu,Xiahai Zhuang,Xinzhe Luo,Shuman Jia,Maxime Sermesant,Yashu Liu,Kuanquan Wang,Davide Borra,Alessandro Masci,Cristiana Corsi,Coen de Vente,Mitko Veta,Rashed Karim,Chandrakanth Jayachandran Preetha,Sandy Engelhardt,Menyun Qiao,Yuanyuan Wang,Qian Tao,Marta Nuñez-Garcia,Oscar Camara,Nicoló Savioli,Pablo Lamata,Jichao Zhao +43 more
TL;DR: This large-scale benchmarking study makes a significant step towards much-improved segmentation methods for atrial LGE-MRIs, and will serve as an important benchmark for evaluating and comparing the future works in the field.
327
Robust ECG signal classification for detection of atrial fibrillation using a novel neural network
Zhaohan Xiong,Martin K. Stiles,Jichao Zhao +2 more
- 14 Sep 2017
TL;DR: A novel CNN with skip connections is demonstrated to perform efficient, automatic ECG signal classification that could potentially aid robust patient diagnosis in real time.
220
ECG signal classification for the detection of cardiac arrhythmias using a convolutional recurrent neural network.
Zhaohan Xiong,Martyn P. Nash,Elizabeth Cheng,Vadim V. Fedorov,Martin K. Stiles,Martin K. Stiles,Jichao Zhao +6 more
TL;DR: Song et al. as mentioned in this paper used a 21-layer 1D convolutional recurrent neural network (RNN) to classify ECGs of different rhythms including atrial fibrillation (AF).
Fully Automatic Left Atrium Segmentation From Late Gadolinium Enhanced Magnetic Resonance Imaging Using a Dual Fully Convolutional Neural Network
TL;DR: This work has developed AtriaNet, a 16-layer convolutional neural network (CNN) that was tested on the largest known data set for LA segmentation, and to the best of the knowledge, it is the most robust approach that has ever been developed for segmenting LGE-MRIs.
Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations
Roberto Piersanti,Pasquale Claudio Africa,Marco Fedele,Christian Vergara,Luca Dedè,Antonio F. Corno,Alfio Quarteroni,Alfio Quarteroni +7 more
TL;DR: This work provides a unified framework, based on LDRBMs, for generating full heart muscle fibers and proposes, for the first time, a LDRBM to be used for generating atrial fibers.
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References
Driver Domains in Persistent Atrial Fibrillation
Michel Haïssaguerre,Mélèze Hocini,Arnaud Denis,Ashok J. Shah,Yuki Komatsu,Seigo Yamashita,Matthew Daly,Sana Amraoui,Stephan Zellerhoff,Marie-Quitterie Picat,Adam Quotb,Laurence Jesel,Han S. Lim,Sylvain Ploux,Pierre Bordachar,Guillaume Attuel,Valentin Meillet,Philippe Ritter,Nicolas Derval,Frederic Sacher,Olivier Bernus,Hubert Cochet,Pierre Jaïs,Rémi Dubois +23 more
TL;DR: Persistent AF in early months is maintained predominantly by drivers clustered in a few regions, most of them being unstable reentries.
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Mother rotors and fibrillatory conduction: a mechanism of atrial fibrillation
TL;DR: Analysis of historical data and more recent experimental evidence behind the hypothesis that AF may be organized by one, or a small number of high-frequency reentrant sources localized in the left atrium discusses the potential implications and evidence supporting such a hypothesis for human AF.
629
Electropathological substrate of long-standing persistent atrial fibrillation in patients with structural heart disease: longitudinal dissociation.
Maurits A. Allessie,Natasja M.S. de Groot,Richard P. M. Houben,Ulrich Schotten,Eric Boersma,Joep L.R.M. Smeets,Harry J.G.M. Crijns +6 more
TL;DR: Electric dissociation of neighboring atrial muscle bundles is a key element in the development of the substrate of human fibrillatory process in patients with normal sinus rhythm and long-standing persistent AF.
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Left atrial anatomy revisited.
TL;DR: This review of anatomy revisits the left atrium, inside as well as outside, for a better understanding of the atrial component parts and the spatial relationships of specific structures.
346
Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern.
Sohail Zahid,Hubert Cochet,Hubert Cochet,Patrick M. Boyle,Erica L. Schwarz,Kaitlyn N. Whyte,Edward J. Vigmond,Rémi Dubois,Mélèze Hocini,Mélèze Hocini,Michel Haïssaguerre,Michel Haïssaguerre,Pierre Jaïs,Pierre Jaïs,Natalia A. Trayanova,Natalia A. Trayanova +15 more
TL;DR: Patient-derived models demonstrate that AF in fibrotic substrates is perpetuated by RDs persisting in fibrosis boundary zones characterized by specific regional fibrosis metrics (high FE and FD).
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