Journal Article10.1055/S-0036-1589048
Thieme Chemistry Journals Awardees – Where Are They Now?Titanium-Catalyzed Hydroaminoalkylation of Vinylsilanes and a One-Pot Procedure for the Synthesis of 1,4-Benzoazasilines
22
TL;DR: In this article, a 2-bromophenylvinyl-silane combined with a subsequent intramolecular Buchwald-Hartwig amination result in the development of an elegant one-pot procedure for the synthesis of 1,4-benzoazasilines.
read more
Abstract: Vinylsilanes undergo intermolecular alkene hydroaminoalkylation with secondary amines in the presence of a titanium mono(aminopyridinato) catalyst to give the branched hydroaminoalkylation products with high regioselectivity. Corresponding reactions of a suitable (2-bromophenyl)vinylsilane combined with a subsequent intramolecular Buchwald–Hartwig amination result in the development of an elegant one-pot procedure for the synthesis of 1,4-benzoazasilines.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
3d Transition Metals for C-H Activation.
Parthasarathy Gandeepan,Thomas Müller,Daniel Zell,Gianpiero Cera,Svenja Warratz,Lutz Ackermann +5 more
TL;DR: A comprehensive overview on first row transition metal catalysts for C-H activation until summer 2018 is provided.
1.8K
Buchwald-Hartwig reaction: An overview
TL;DR: In this article, the Buchwald-Hartwig amination reaction has attracted much attention in recent years, especially applied for construction of various heterocyclic systems, and the applications of this name reaction as an important C-N cross-coupling reaction applied to the total synthesis of natural products.
194
Titanium catalysis for the synthesis of fine chemicals – development and trends
Manfred Manßen,Laurel L. Schafer +1 more
TL;DR: An overview of historic inspirational contributions, both catalytic and stoichiometric, and the latest insights in catalyst design efforts, mechanistic details and utility of the three different classes of transformations in titanium catalysis are provided.
139
3-Silaazetidine: An Unexplored yet Versatile Organosilane Species for Ring Expansion toward Silaazacycles.
TL;DR: 3-Silaazetidine as discussed by the authors is a unique small ring silacycle bearing silicon and nitrogen atoms, which has not been adequately explored due to the lack of a general synthetic scheme and its sensitivity to air.
38
Hydroaminoalkylation/Buchwald-Hartwig amination sequences for the synthesis of benzo-annulated seven-membered nitrogen heterocycles
Tobias Kaper,Sven Doye +1 more
TL;DR: In this article, a reaction sequence consisting of an initial intermolecular titanium-catalyzed hydroaminoalkylation of a suitably ortho-bromophenyl-substituted alkene and a subsequent intramolecular Buchwald-Hartwig amination is used for the synthesis of benzazepine derivatives.
17
References
Si- and C-Functional Organosilicon Building Blocks for Synthesis Based on 4-Silacyclohexan-1-ones Containing the Silicon Protecting Groups MOP (4-Methoxyphenyl), DMOP (2,6-Dimethoxyphenyl), or TMOP (2,4,6-Trimethoxyphenyl).
TL;DR: The C- and Si-functional compounds 1a-1c, 2a-2c, 3a-3c, 4a-4c, 5a, and 5b represent versatile building blocks for synthesis.
18
Ir(I)-Catalyzed Enantioselective Secondary sp3 C–H Bond Activation of 2-(Alkylamino)pyridines with Alkenes
TL;DR: The reaction of 2-(alkylamino)pyridines with various alkenes gave chiral amines in good yields with high enantiomeric excesses.
Selective C−H Activation α to Primary Amines. Bridging Metallaaziridines for Catalytic, Intramolecular α-Alkylation
TL;DR: Preliminary mechanistic investigations suggest bridging metallaaziridine species are the catalytically active intermediates for this alpha-functionalization reaction, while monomeric imido complexes furnish azepane hydroamination products.
Synthesis and Structure of Group 4 Symmetric Amidinate Complexes and Their Reactivity in the Polymerization of α-Olefins
Tatyana Elkin,Naveen V. Kulkarni,Boris Tumanskii,Mark Botoshansky,Linda J. W. Shimon,Moris S. Eisen +5 more
TL;DR: The steric properties of various nitrogen substituents on amidines were tuned in order to obtain group 4 mono-and bis(amidinate) dimethylamido or chloride complexes.