Patent
Therapeutic uses of bactericidal/permeability increasing protein products
William Steve Ammons,Little Roger G +1 more
- 11 Mar 1994
79
TL;DR: In this paper, a method for treatment of conditions including neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing protein products is presented.
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Abstract: The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products.
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Citations
Patent
Cysteine-pegylated proteins
Scott Michael Braxton
- 21 Apr 1995
TL;DR: In this article, a method and compositions for the production of PEGylated proteins having polyethylene glycol covalently bound to a cysteine residue present in either the naturally-occurring protein or introduced by site-specific mutation.
167
Patent
Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
II Roger G. Little
- 11 Mar 1994
TL;DR: In this paper, the authors provide peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses, including bactericidal and permeability-increasing protein (BPI) functional domains.
72
Patent
Anti-gram-positive bacterial methods and materials
Arnold Horwitz,Lambert Lewis H,II Roger G. Little +2 more
- 13 Jan 1995
TL;DR: In this article, a method of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic was proposed, which has a bactericidal or growth inhibitory effect on selected gram positive organisms.
54
Patent
Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
Lesa J. Beamer,Stephen F. Carroll,David Eisenberg +2 more
- 20 Jun 1997
TL;DR: In this paper, a crystallized Bactericidal Permeability-Increasing (BPI) protein and methods for x-ray diffraction analysis to provide 3D structure determination of the protein were presented.
47
Patent
Stable bactericidal/permeability-increasing protein products and pharmaceutical compositions containing the same
Theofan Georgia,Arnold Horwitz,David Burke,Baltaian Manik,Grinna Lynn +4 more
- 02 Feb 1994
TL;DR: In this paper, novel bactericidal/permeability-increasing (BPI) protein products where cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue are presented.
46
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