The volatile microbiome
TL;DR: The first detailed temporal study of the human microbiome shows that individual body habitats exhibit surprising variation over time yet maintain distinguishable community structures.
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Abstract: The first detailed temporal study of the human microbiome shows that individual body habitats exhibit surprising variation over time yet maintain distinguishable community structures
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Citations
Volatility as a Concept to Understand the Impact of Stress on the Microbiome.
Thomaz F.S. Bastiaanssen,Anand Gururajan,Marcel van de Wouw,Gerard M. Moloney,Nathaniel L. Ritz,Caitriona M. Long-Smith,Niamh Wiley,A Murphy,Joshua M. Lyte,Fiona Fouhy,Catherine Stanton,Marcus J. Claesson,Timothy G. Dinan,John F. Cryan +13 more
TL;DR: The volatility of the microbiome is significantly correlated with several readouts of the stress response, including behaviour and corticosterone response, and inter-species similarities in the microbiome stress response on a functional level are found.
80
Oil sands tailings ponds harbour a small core prokaryotic microbiome and diverse accessory communities.
Sandra L. Wilson,Carmen Li,Esther Ramos-Padron,Camilla L. Nesbø,Jung Soh,Christoph Wilhelm Sensen,Christoph Wilhelm Sensen,Gerrit Voordouw,Julia M. Foght,Lisa M. Gieg +9 more
TL;DR: The prokaryotic communities within oil sands tailings ponds consist of a few core taxa and numerous accessory members that likely afford resiliency and functional redundancy including roles in iron-, nitrogen- and sulfur-cycling, syntrophy, fermentation, and methanogenesis.
27
Bugs as Features (Part I): Concepts and Foundations for the Compositional Data Analysis of the Microbiome-Gut-Brain Axis
Thomaz F.S. Bastiaanssen,Thomas P. Quinn,Amy Loughman +2 more
- 25 Jul 2022
TL;DR: In this article , the authors present a perspective on the concepts and foundations of data analysis and interpretation of microbiome experiments with a focus on the microbiome-gut-brain axis domain.
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Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury
Adam Doelman,Seth Tigchelaar,Brian McConeghy,Sunita Sinha,Martin S. Keung,Neda Manouchehri,Megan Webster,Shera Fisk,Charlotte J. Morrison,Femke Streijger,Corey Nislow,Brian K. Kwon +11 more
TL;DR: In this paper, the authors characterized the composition of the gut microbiome in a Yucatan minipig SCI model and compared the relative abundance of the most dominant bacterial phyla in control samples to those collected from animals who underwent a contusion-compression SCI at the 2nd or 10th thoracic level.
Systems and Network-Based Approaches for Personalized Medicine
Sarath Ch,ra Janga,Mohan Mallikarjuna Rao Edupuganti +2 more
- 02 Nov 2014
TL;DR: This work states that systems/network-based approaches are not only enabling us to develop models of disease and wellness in a population but also contributing to the authors' efforts to reverse engineer the molecular networks corresponding to disease states by perturbing using drug cocktails.
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References
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample
J. Gregory Caporaso,Christian L. Lauber,William A. Walters,Donna Berg-Lyons,Catherine A. Lozupone,Peter J. Turnbaugh,Noah Fierer,Rob Knight +7 more
TL;DR: This work sequences a diverse array of 25 environmental samples and three known “mock communities” at a depth averaging 3.1 million reads per sample to demonstrate excellent consistency in taxonomic recovery and recapture diversity patterns that were previously reported on the basis of metaanalysis of many studies from the literature.
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Peter J. Turnbaugh,Vanessa K. Ridaura,Jeremiah J. Faith,Federico E. Rey,Rob Knight,Jeffrey I. Gordon +5 more
TL;DR: A translational medicine pipeline is described where human gut microbial communities and diets are re-created in gnotobiotic mice and the impact on microbe and host is defined using metagenomics, creating a well-defined, representative animal model of the human gut ecosystem.
Development of the human infant intestinal microbiota.
Chana Palmer,Elisabeth M. Bik,Daniel B. DiGiulio,Daniel B. DiGiulio,David A. Relman,David A. Relman,Patrick O. Brown +6 more
TL;DR: A microarray is designed to detect and quantitate the small subunit ribosomal RNA (SSU rRNA) gene sequences of most currently recognized species and taxonomic groups of bacteria and suggested that incidental environmental exposures play a major role in determining the distinctive characteristics of the microbial community in each baby.
The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing
TL;DR: Ciprofloxacin treatment influenced the abundance of about a third of the bacterial taxa in the gut, decreasing the taxonomic richness, diversity, and evenness of the community, and support the hypothesis of functional redundancy in the human gut microbiota.
Succession of microbial consortia in the developing infant gut microbiome
Jeremy E. Koenig,Aymé Spor,Nicholas B. Scalfone,Ashwana D. Fricker,Jesse Stombaugh,Rob Knight,Largus T. Angenent,Ruth E. Ley +7 more
TL;DR: This study revealed that seemingly chaotic shifts in the microbiome are associated with life events; however, additional experiments ought to be conducted to assess how different infants respond to similar life events.
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