The usefulness of serum transferrin receptor for discriminating iron deficiency without anemia in children.
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TL;DR: The levels of sTfR were significantly higher in children with storage iron deficiency but had a poor sensivity for recognizing iron deficiency without anemia.
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Abstract: We determined serum transferrin receptor (sTfR), serum erythropoietin and hematologic and biochemical iron parameters in 251 healthy children. The levels of sTfR were significantly higher in children with storage iron deficiency but had a poor sensivity for recognizing iron deficiency without anemia. When ferritin values cannot accurately demonstrate the iron deficiency in children, the sTfR/ferritin ratio or sTfR-log ferritin is recommended to discriminate iron deficiency in the absence of anemia.
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References
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
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Soluble transferrin receptor for the evaluation of erythropoiesis and iron status.
TL;DR: It is concluded that soluble TfR represents a valuable quantitative assay of marrow erythropoietic activity as well as a marker of tissueIron deficiency, a situation defined by tissue iron deficiency despite adequate iron stores.
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The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status
TL;DR: A novel method of calculating the LogTfR:Fer ratio may provide a more precise classification of the iron status of children.
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Regression-based Reference Limits for Serum Transferrin Receptor in Children 6 Months to 16 Years of Age
Pauli Suominen,Arja Virtanen,Marjo Lehtonen-Veromaa,Olli J. Heinonen,Toivo T. Salmi,Markku Alanen,Timo Möttönen,Allan Rajamäki,Kerttu Irjala +8 more
TL;DR: The purpose was to demonstrate consistent age-dependent changes in sTfR concentrations and to establish appropriate reference limits to enable the use of sTFR measurements in routine pediatric clinical practice.
•Journal Article
Serum transferrin receptor in healthy children
Vázquez López Mf,Carracedo Morales A,Muñoz Vico J,Morcillo Llorens R,Calvo Bonachera,López Muñoz J,Muñoz Hoyos A +6 more
TL;DR: Serum transferrin receptor concentrations are elevated in children due to increased iron requirements for growth and in healthy children sTfR concentrations are related to erythropoietic activity and intracellular iron requirements.
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