Journal Article10.1016/J.ARR.2005.03.003
The stress system in the human brain in depression and neurodegeneration.
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TL;DR: It is hypothesized that particularly a subgroup of CRH neurons that projects into the brain is activated in depression and induces the symptoms of this disorder, which is a basis for the higher prevalence of mood disorders in women as compared to men.
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About: This article is published in Ageing Research Reviews. The article was published on 01 May 2005. The article focuses on the topics: Corticotropin-releasing hormone & Chronic stress.
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Citations
From inflammation to sickness and depression: when the immune system subjugates the brain
TL;DR: In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
TL;DR: Because the MPFC and related limbic structures provide forebrain modulation over visceral control structures in the hypothalamus and brainstem, their dysfunction can account for the disturbances in autonomic regulation and neuroendocrine responses that are associated with mood disorders.
Neurocircuitry of Mood Disorders
Joseph L. Price,Wayne C. Drevets +1 more
TL;DR: A system has been described that links the medial prefrontal cortex and a few related cortical areas to the amygdala, the ventral striatum and pallidum, the medial thalamus, the hypothalamus, and the periaqueductal gray and other parts of the brainstem, which indicates that this system is centrally involved in mood disorders.
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Depression and risk of developing dementia
TL;DR: Current evidence linking late-life and earlier-life depression and dementia, and the primary underlying mechanisms and implications for treatment are summarized and analyzed.
Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies
P. Cédric M. P. Koolschijn,Neeltje E.M. van Haren,Gerty J. L. M. Lensvelt-Mulders,Hilleke E. Hulshoff Pol,René S. Kahn +4 more
TL;DR: This is the first comprehensive meta‐analysis in major depressive disorder demonstrating structural brain abnormalities, particularly in those brain areas that are involved in emotion processing and stress‐regulation.
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References
Neurogenesis in the adult human hippocampus
Peter S. Eriksson,Ekaterina Perfilieva,Thomas Björk-Eriksson,Ann Marie Alborn,Claes Nordborg,Daniel A. Peterson,Fred H. Gage +6 more
TL;DR: It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
TL;DR: Preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness.
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Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.
TL;DR: Evidence is provided for the importance of parental care as a mediator of the effects of environmental adversity on neural development and patterns of maternal care that increase stress reactivity in offspring are enhanced by stressors imposed on the mother.
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Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation
TL;DR: It is concluded that CORT action via CR may be involved in a tonic (permissive) influence on brain function with the septohippocampal complex as a primary target.
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Gender Differences in Depression
TL;DR: For example, this article found that women are twice as likely as men to experience depression from early adolescence through adulthood, and that gender differences in stress experiences and stress reactivity may interact to create women's greater vulnerability to depression.