The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease

TL;DR: In this paper , the authors discuss how early initiated cells are protected from further tumorigenesis and the non-mutagenic pathways by which cancer risk factors promote tumor growth, and consider existing strategies for early cancer interception with perspectives on the next steps for molecular cancer prevention.

TL;DR: The various components of the immune TME in breast cancer and therapies that target or impact the immune TME are discussed, as well as the complexity of host physiology.

TL;DR: In this article , the authors propose that ageing is not due to inevitable damage to the hardware but rather because of intrinsic design flaws in the software, defined as the DNA code that orchestrates how a single cell develops into an adult organism and suggest that to understand ageing we need to decode our software and the flow of epigenetic information throughout the life course.

TL;DR: In this article , the authors synthesize reflections on the current literature linking cancer and aging, with an eye on fundamental aging processes, such as cellular senescence, and consider how interventions that target fundamental aging process can potentially transform cancer care, from preventing cancer development and progression to reducing the burden of accelerated aging in cancer survivors.

TL;DR: This analysis updates the widely-cited 10:1 ratio, showing that the number of bacteria in the body is actually of the same order as the numberof human cells, and their total mass is about 0.2 kg.

TL;DR: This analysis updates the widely-cited 10:1 ratio, showing that the number of bacteria in the authors' bodies is actually of the same order as thenumber of human cells.

TL;DR: It is argued that chronic diseases are not only the result of ageing and inflammaging; these diseases also accelerate the ageing process and can be considered a manifestation of accelerated ageing, and the use of new biomarkers capable of assessing biological versus chronological age in metabolic diseases is proposed.

TL;DR: It is now becoming clear that p53 can have a much broader role and can contribute to the development, life expectancy and overall fitness of an organism.