Journal Article10.1016/J.TIBS.2003.11.004
The riboswitch control of bacterial metabolism.
Evgeny Nudler,Alexander Mironov +1 more
627
TL;DR: Recent progress in the identification and characterization of riboswitches are summarized and discussed and their evolution and distribution are discussed.
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About: This article is published in Trends in Biochemical Sciences. The article was published on 01 Jan 2004. The article focuses on the topics: PreQ1 riboswitch & Riboswitch.
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Citations
Regulatory RNAs in Bacteria
Lauren S. Waters,Gisela Storz +1 more
TL;DR: The known mechanisms and roles of regulatory RNAs are reviewed, emerging themes are highlighted, and remaining questions are discussed.
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Gene regulation by riboswitches.
Maumita Mandal,Ronald R. Breaker +1 more
TL;DR: New findings indicate that riboswitches are robust genetic elements that are involved in regulating fundamental metabolic processes in many organisms.
TonB-Dependent Transporters: Regulation, Structure, and Function
TL;DR: Recent progress in understanding regulation, structure, and function in TBDTs is summarized and questions remaining to be answered are summarized.
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
TL;DR: Aptamers selected from chemically modified libraries can be completely resistant toward degradation by nucleases, and can lead to ligands with novel chemical functionalities normally not present in natural nucleic acids.
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Regulation of bacterial gene expression by riboswitches
TL;DR: Riboswitches are structured domains that usually reside in the noncoding regions of mRNAs, where they bind metabolites and control gene expression and form highly specific binding pockets for the target metabolite.
797
References
Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression
TL;DR: It is reported here that mRNAs encoding enzymes involved in thiamine (vitamin B1) biosynthesis in Escherichia coli can bindThiamine or its pyrophosphate derivative without the need for protein cofactors and provides an example of a 'riboswitch' whose evolutionary origin might pre-date the emergence of proteins.
1.3K
Genetic Control by a Metabolite Binding mRNA
Ali Nahvi,Narasimhan Sudarsan,Margaret S. Ebert,Xiang Zou,Kenneth L. Brown,Ronald R. Breaker +5 more
TL;DR: This finding, along with related observations, supports the hypothesis that metabolic monitoring through RNA-metabolite interactions is a widespread mechanism of genetic control.
888
Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria
TL;DR: This work has identified a class of riboswitches that selectively recognizes guanine and becomes saturated at concentrations as low as 5 nM, and it is now apparent that ribosWitches contribute to the regulation of numerous fundamental metabolic pathways in certain bacteria.
824
An mRNA structure that controls gene expression by binding FMN
TL;DR: Sequence and structural analyses indicate that the RFN element is a natural FMN-binding aptamer, the allosteric character of which is harnessed to control gene expression.
765
Sensing Small Molecules by Nascent RNA: A Mechanism to Control Transcription in Bacteria
Alexander Mironov,Ivan Gusarov,Ruslan Rafikov,Lubov Errais Lopez,Konstantin Shatalin,R. A. Kreneva,D. A. Perumov,Evgeny Nudler +7 more
TL;DR: It is demonstrated that the feedback regulation of riboflavin and thiamin genes relies on a novel transcription attenuation mechanism that involves the formation of specific complexes between a conserved leader region of the cognate RNA and FMN or TPP.
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