The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders.
Emily L. Casanova,Carolina Baeza-Velasco,Carolina Baeza-Velasco,Caroline B. Buchanan,Manuel F. Casanova,Manuel F. Casanova +5 more
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TL;DR: The overlap between EDS/HSD and autism is addressed, including neurobehavioral, psychiatric, and neurological commonalities, shared peripheral neuropathies and neuropathologies, and similar autonomic and immune dysregulation.
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Abstract: Considerable interest has arisen concerning the relationship between hereditary connective tissue disorders such as the Ehlers-Danlos syndromes (EDS)/hypermobility spectrum disorders (HSD) and autism, both in terms of their comorbidity as well as co-occurrence within the same families. This paper reviews our current state of knowledge, as well as highlighting unanswered questions concerning this remarkable patient group, which we hope will attract further scientific interest in coming years. In particular, patients themselves are demanding more research into this growing area of interest, although science has been slow to answer that call. Here, we address the overlap between these two spectrum conditions, including neurobehavioral, psychiatric, and neurological commonalities, shared peripheral neuropathies and neuropathologies, and similar autonomic and immune dysregulation. Together, these data highlight the potential relatedness of these two conditions and suggest that EDS/HSD may represent a subtype of autism.
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Citations
The Links Between Fibromyalgia, Hypermobility and Neurodivergence
TL;DR: Screening patients with fibromyalgia and hypermobility for neurodivergent traits and vice versa may facilitate diagnosis and management of these conditions.
Autism and chronic ill health: an observational study of symptoms and diagnoses of central sensitivity syndromes in autistic adults
TL;DR: The reliability and validity of the Central Sensitization Inventory (CSI) in an autistic sample was established using exploratory and confirmatory factor analyses as mentioned in this paper , with sensory sensitivity, anxiety, age and gender being significant predictors of CSS symptoms.
Updates on the psychological and psychiatric aspects of the Ehlers-Danlos syndromes and hypermobility spectrum disorders.
Andrea Bulbena-Cabre,Carolina Baeza-Velasco,Carolina Baeza-Velasco,Silvia Rosado-Figuerola,Antonio Bulbena +4 more
TL;DR: The field of the psychiatric and psychological aspects of Ehlers-Danlos syndromes (EDS) has been understudied and neglected for many years as discussed by the authors, however, research on the biological basis of EDS is improving our understanding of the physiology and psychopathology of the disorder.
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Autism and Chronic Ill Health: An Observational Study of Symptoms and Diagnoses of Central Sensitivity Syndromes in Autistic Adults
Grant Sl,Norton S,Weiland Rf,Scheeren Am,Begeer S,Hoekstra Ra +5 more
- 07 Jun 2021
TL;DR: Investigation of the occurrence of CSS diagnoses and symptoms in autistic adults found nonbinary and female autistics were more likely to report a CSS diagnosis and experienced more CSS symptoms than males, and sensory sensitivity, anxiety, age and sex were significant predictors of CSS symptoms.
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