The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress
TL;DR: The natural occurring compounds targeting ER stress, which results in medical benefits to human diseases, mainly include polyphenols, alkaloids, and saponins are summarized.
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Abstract: ER stress has been implicated in pathophysiological development of many diseases. Persistent overwhelming stimuli trigger ER stress to initiate apoptosis, autophagy, and cell death. IRE1-JNK and eIF2α-CHOP signaling pathways are the two important players of ER stress, which is also modulated by ROS production, calcium disturbance, and inflammatory factors. ER stress has been developed as a novel strategy for diseases management. Recently, a vast of research focuses on the natural occurring compounds targeting ER stress, which results in medical benefits to human diseases. These small reported molecules mainly include polyphenols, alkaloids, and saponins. Many of them have been developed for use in clinical applications. To better understand the pharmacological mechanism of these molecules in ER stress in diseases, efforts have been made to discover and deliver medical merits. In this paper, we will summarize the natural occurring compounds targeting ER stress.
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References
Role of the Calcium-Sensing Receptor in Cardiomyocyte Apoptosis via the Sarcoplasmic Reticulum and Mitochondrial Death Pathway in Cardiac Hypertrophy and Heart Failure
Fanghao Lu,Songbin Fu,Xiaoning Leng,Xinying Zhang,Shiyun Dong,Yajun Zhao,Huan Ren,Hulun Li,Xin Zhong,Changqing Xu,Weihua Zhang +10 more
TL;DR: It is demonstrated that CaR activation caused Ca2+ release from the SR into the mitochondria and induced cardiomyocyte apoptosis through the SR and mitochondrial apoptotic pathway in failing hearts.
Autophagy Is Activated for Cell Survival after Endoplasmic Reticulum Stress
Maiko Ogata,Shin-ichiro Hino,Atsushi Saito,Keisuke Morikawa,Shinichi Kondo,Soshi Kanemoto,Tomohiko Murakami,Manabu Taniguchi,Ichiro Tanii,Kazuya Yoshinaga,Sadao Shiosaka,James A. Hammarback,Fumihiko Urano,Kazunori Imaizumi +13 more
TL;DR: It is found that the autophagy system is activated as a novel signaling pathway in response to ER stress and played important roles in cell survival after ER stress.
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Inki Kim,Wenjie Xu,John C. Reed +2 more
TL;DR: The accumulation of unfolded proteins in the endoplasmic reticulum represents a cellular stress induced by multiple stimuli and pathological conditions, which triggers an evolutionarily conserved series of signal-transduction events, which constitutes the unfolded protein response.
1.8K
ER-associated degradation: Protein quality control and beyond
TL;DR: The best characterized pathway, the ER-associated protein degradation (ERAD), monitors the folding of membrane and secretory proteins whose biogenesis takes place in the endoplasmic reticulum (ER).
CHOP is a multifunctional transcription factor in the ER stress response.
TL;DR: CCAAT-enhancer-binding protein homologous protein (CHOP) is induced by ER stress and mediates apoptosis and the multifunctional roles of CHOP in the ER stress response are discussed below.
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