Journal Article10.1016/S0145-305X(03)00027-2
The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes.
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TL;DR: 'The Mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes' 'IMGT Locus in Focus' report provides the first complete list of the mouse TRAV and TRDV genes which span 1550 kb on chromosome 14 at 19.7 cM.
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Abstract: 'The Mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes' 'IMGT Locus in Focus' report provides the first complete list of the mouse TRAV and TRDV genes which span 1550 kb on chromosome 14 at 19.7 cM. The total number of TRAV genes per haploid genome is 98 belonging to 23 subgroups. This includes 10 TRAV/DV genes which belong to seven subgroups. The functional TRAV genomic repertoire comprises 72-82 TRAV (including 9-10 TRAV/DV) belonging to 19 subgroups. The total number of TRDV genes per haploid genome is 16 (including the 10 TRAV/DV) belonging to 12 subgroups. The functional TRDV genomic repertoire comprises 14-15 genes (5 TRDV and 9-10 TRAV/DV) belonging to 11-12 subgroups. The eight tables and three figures of this report are available at the IMGT Marie-Paule page of IMGT. The international ImMunoGeneTics information system (http://imgt.cines.fr) created by Marie-Paule Lefranc, Universite Montpellier II, CNRS, France.
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Citations
T cell fate and clonality inference from single-cell transcriptomes
Michael J. T. Stubbington,Tapio Lönnberg,Valentina Proserpio,Simon Clare,Anneliese O. Speak,Gordon Dougan,Sarah A. Teichmann,Sarah A. Teichmann +7 more
TL;DR: It is found that T cell clonotypes in a mouse Salmonella infection model span early activated CD4+ T cells as well as mature effector and memory cells.
IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties.
Christelle Pommié,Séverine Levadoux,Robert Sabatier,Gérard Lefranc,Marie-Paule Lefranc,Marie-Paule Lefranc +5 more
TL;DR: The standardized criteria defined in this paper, amino acid positions and property classes, will be useful to study the mutations and allele polymorphisms, to establish correlations between amino acids in the IG and TR protein three‐dimensional structures and to extract new knowledge from V‐like domains of chains, other than IG andTR, belonging to the immunoglobulin superfamily.
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Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes.
Jane A. Skok,Jane A. Skok,Ramiro Gisler,Maria Novatchkova,Deborah Farmer,Wouter de Laat,Meinrad Busslinger +6 more
TL;DR: Pericentromeric recruitment and locus 'decontraction' seem to contribute to the initiation and maintenance of allelic exclusion at the Tcrb locus.
161
•Journal Article
IMGT-ONTOLOGY for immunogenetics and immunoinformatics.
Marie-Paule Lefranc,Véronique Giudicelli,Chantal Ginestoux,Nathalie Bosc,Géraldine Folch,Delphine Guiraudou,Joumana Jabado-Michaloud,Séverine Magris,Dominique Scaviner,Valérie Thouvenin,Kora Combres,David Girod,Stéphanie Jeanjean,Céline Protat,Mehdi Yousfi Monod,Elodie Duprat,Quentin Kaas,Christelle Pommié,Denys Chaume,Gérard Lefranc +19 more
TL;DR: IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins, T cell receptors, major histocompatibility complex and related proteins of the immune system of human and other vertebrates.
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•Journal Article
IMGT-Choreography for Immunogenetics and Immunoinformatics
Marie-Paule Lefranc,Oliver Clement,Quentin Kaas,Elodie Duprat,Patrick Chastellan,Isabelle Coelho,Kora Combres,Chantal Ginestoux,Véronique Giudicelli,Denys Chaume,Gérard Lefranc +10 more
TL;DR: IMGT-Choreography will further increase the IMGT leadership in immunogenetics and immunoinformatics for medical research, and will trigger and coordinate dynamic interactions between IMGT Web services to process complex significant biological and clinical requests.
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IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains.
Marie-Paule Lefranc,Christelle Pommié,Quentin Kaas,Elodie Duprat,Nathalie Bosc,Delphine Guiraudou,Christelle Jean,Manuel Ruiz,Isabelle Da Piédade,Mathieu Rouard,Elodie Foulquier,Valérie Thouvenin,Gérard Lefranc +12 more
TL;DR: The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C- DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMains andC-LIke-DOMains of proteins other than IG andTR, in any species.
IMGT, the international ImMunoGeneTics database.
TL;DR: IMGT goals are to establish a common data access to all immunogenetics data, including nucleotide and protein sequences, oligonucleotide primers, gene maps and other genetic data of Ig, TcR and MHC molecules, and to provide a graphical user friendly data access.
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
Hans Acha-Orbea,Dennis J. Mitchell,Luika Timmermann,David C. Wraith,Gilbert S. Tausch,Matthew K. Waldor,Scott S. Zamvil,Hugh O. McDevitt,Lawrence Steinman +8 more
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TL;DR: The traditional numbering of V gene segments in the order of their discovery was continued and changed when in conflict with names of other segments, and the number of more than 150 different TCRBV sequences in the database was reduced to a repertoire of only 47 functional T CRBV gene segments.
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