Journal Article10.1016/J.GDE.2005.09.006
The microbial pan-genome
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TL;DR: A decade after the beginning of the genomic era, the question of how genomics can describe a bacterial species has not been fully addressed and the pan-genome, which is composed of a "core genome" containing genes present in all strains, and a "dispensable genome", might be orders of magnitude larger than any single genome.
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About: This article is published in Current Opinion in Genetics & Development. The article was published on 01 Dec 2005. The article focuses on the topics: Minimal genome & Bacterial genome size.
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Citations
Azotobacter Genomes: The Genome of Azotobacter chroococcum NCIMB 8003 (ATCC 4412)
TL;DR: The genome of the soil-dwelling heterotrophic N2-fixing Gram-negative bacterium Azotobacter chroococcum NCIMB 8003 (ATCC 4412) (Ac-8003) has been determined and the core biosynthetic and metabolic pathways and macromolecular architectures and machineries of these organisms appear largely conserved.
Mechanisms That Shape Microbial Pangenomes.
TL;DR: In this article, the authors describe how gene content variation can arise as a result of the combination of several processes, including random drift, selection, gain/loss balance, and the influence of ecological and epistatic interactions.
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Bacterial genome variability and its impact on vaccine design.
TL;DR: The efficacy of more recently developed vaccines is limited by antigen variation, which also presents a challenge for future vaccine development.
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The Global Transcriptional Responses of Bacillus anthracis Sterne (34F2) and a ΔsodA1 Mutant to Paraquat Reveal Metal Ion Homeostasis Imbalances during Endogenous Superoxide Stress
TL;DR: Analysis of paraquat-induced global transcriptional response of Bacillus anthracis Sterne to varying levels of endogenous superoxide stress revealed that the transcription of genes putatively involved in metal/ion transport, bacillibactin siderophore biosynthesis, the glyoxalase pathway, and oxidoreductase activity was perturbed most significantly.
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Pan-genome analysis of Bacillus for microbiome profiling.
TL;DR: This study comprehensively analyzed 238 strains of five different Bacillus species to identify the properties of core and strain-specific genes and provides a comprehensive genetic landscape of the Bacillus Species, which is consistent with previous studies on a limited number of strains and species.
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Phages and the Evolution of Bacterial Pathogens: from Genomic Rearrangements to Lysogenic Conversion
TL;DR: The current review presents the available genomics and biological data on prophages from bacterial pathogens in an evolutionary framework to demonstrate that the chromosomes from bacteria and their viruses (bacteriophages) are coevolving.
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