The microbial pan-genome

TL;DR: Reverse vaccinology changed the way to think about vaccine development, using the information provided by the microorganisms' genome against themselves, and led to the discovery and development of novel vaccines concerning emerging diseases.

TL;DR: The primary goal was to identify relationships that can assist in reducing the high false positive rates associated with transcription factor binding site predictions and thereupon enhance the reliability of the inferred transcription regulatory networks.

TL;DR: A scaled energy minimization model is presented to test the feasibility of deriving a composite biological interaction network from multiple constituent data sets using the Hebbian learning principle, and the results are compared against the standard Hopfield model using simulated data.

TL;DR: The degree of correspondence between the vaginal and the rectal microflora is established and the species composition and the genotype similarity for those species simultaneously present in both niches, were unexpectedly high, indicating that indeed the rectum is probably the most important source of the vaginalmicroflora, or that strong dynamic exchange between both nichesis exist.

TL;DR: Over 1.2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors are identified, suggesting substantial oceanic microbial diversity.

TL;DR: The genomic sequence of six strains representing the five major disease-causing serotypes of Streptococcus agalactiae, the main cause of neonatal infection in humans, was generated and Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactic pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes.

TL;DR: Mobile elements within genomes have driven genome evolution in diverse ways and are becoming useful tools for learning more about genome evolution and gene function.

TL;DR: The current review presents the available genomics and biological data on prophages from bacterial pathogens in an evolutionary framework to demonstrate that the chromosomes from bacteria and their viruses (bacteriophages) are coevolving.