Journal Article10.1016/S0749-0690(18)30697-9
The lives of pigment cells.
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TL;DR: Most pigment cells during embryogenesis arise from the cranial or truncal portion of the neural crest and migrate to the skin, hair bulbs, choroid of the eye, the inner ear, leptomeninges, and other tissues, and are involved in the formation of the retina and the optic nerves and tracts.
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About: This article is published in Clinics in Geriatric Medicine. The article was published on 01 Feb 1989. The article focuses on the topics: Retinal pigment epithelium & Retina.
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Citations
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
TL;DR: Melanogenesis is a highly structured system, active since early embryogenesis and capable of superselective functional regulation that may reach down to the cellular level represented by single melanocytes, and its significance extends beyond the mere assignment of a color trait.
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Age- and site-specific variation in the dermoscopic patterns of congenital melanocytic nevi: An aid to accurate classification and assessment of melanocytic nevi
Lily Changchien,Stephen W. Dusza,Anna Liza C. Agero,Adam Korzenko,Ralph P. Braun,Ralph P. Braun,Dana L. Sachs,M. Haris U. Usman,Allan C. Halpern,Ashfaq A. Marghoob +9 more
TL;DR: The results suggest that the predominant dermoscopic patterns ofCMN vary according to age and lesional site, and these differences may inform future studies on the pathogenesis of CMN.
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Primary malignant melanoma of the oesophagus: a clinical and pathological study with emphasis on the immunophenotype of the tumours for melanocyte differentiation markers and cancer/testis antigens.
TL;DR: The clinical and pathological findings of 10 patients with primary oesophageal melanoma are presented, with emphasis on the immunophenotype of the tumours, suggesting that CT antigens may be a promising immunotherapeutic target for oesophileal melanomas.
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•Journal Article
Effect of melanocyte stimulating hormone on human cultured choroidal melanocytes, uveal melanoma cells, and retinal epithelial cells.
TL;DR: Ocular melanocytes show evidence of regulation by MSH and a range of mitogenic stimuli unlike the transformed melanoma cells, implying a loss of regulatory control in the latter.
39
Fundus pigmentation and the dark-adapted electroretinogram.
Naheed Wali,Lawrence E. Leguire +1 more
TL;DR: Dark-adapted electroretinograms obtained over a 3.6-log range of stimulus intensities from 17 black and 15 white normal subjects revealed that subjects with light fundi had larger b-wave amplitudes at all luminance levels, and the relationship between Vmax and fundus pigmentation could not be attributed to age, gender, refractive error, axial length or intraocular pressure.
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References
Neural crest and the origin of vertebrates: a new head.
Carl Gans,R. Glenn Northcutt +1 more
TL;DR: Most of the morphological and functional differences between vertebrates and other chordates occur in the head and are derived embryologically from muscularized hypomere, neural crest, and epidermal (neurogenic) placodes.
1K
The Incidence and Significance of Birthmarks in a Cohort of 4,641 Newborns
Joseph C. Alper,Lewis B. Holmes +1 more
TL;DR: An unselected cohort of 4,641 newborns was ascertained prospectively for the purpose of detecting any cutaneous lesion and several important findings were elucidated, including congenital nevocellular nevi are speckled at their borders.
300
Quantitative and Qualitative Data on the Pigment Cells of Adult Human Epidermis1
TL;DR: The morphology and physiology of the melanocyte have been studied thoroughly by numerous investigators, but conflicting statements concerning several basic points, and insufficient data concerning others were found in recent literature.
292
Pigmented lesions in newborn infants.
TL;DR: In newborn infants it is often impossible clinically to distinguish naevi from other types of pigmented lesions, as only eleven out of the thirty‐four pigmen‐ted lesions were melanocyticNaevi, and none of them showed any suggestion of malignant change.
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