Journal Article10.1016/S0015-0282(16)58569-0
The importance of endogenous feedback for monofollicular growth in low-dose step-up ovulation induction with follicle-stimulating hormone in polycystic ovary syndrome: a randomized study *
Maartje van der Meer,Peter G.A. Hompes,Fedde Scheele,Erik Schoute,Corrie Popp-Snijders,Joop Schoemaker +5 more
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TL;DR: The absence of a decrease of FSH during GnRH-a treatment in association with a lower rate of monofollicular growth suggests that endogenous feedback during low-dose step-up ovulation induction in PCOS plays an important role.
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About: This article is published in Fertility and Sterility. The article was published on 01 Oct 1996. The article focuses on the topics: Polycystic ovary & Follicle-stimulating hormone.
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Citations
Consensus on infertility treatment related to polycystic ovary syndrome
Thessaloniki,Greece. +1 more
TL;DR: The treatment of infertile women with polycystic ovary syndrome (PCOS) is surrounded by many controversies, and a group of experts reached a consensus regarding the therapeutic challenges raised in these women.
891
Urinary follicle-stimulating hormone for normogonadotropic clomiphene-resistant anovulatory infertility: prospective, randomized comparison between low dose step-up and step-down dose regimens.
TL;DR: A step-down protocol for gonadotropin induction of ovulation exhibits a more physiological, late follicular phase FSH serum profile than a low dose step-up protocol, which results in a shorter duration of treatment, a greater number of monofollicular cycles, and more cycles with periovulatory E2 levels within the normal range in the step- down protocol.
Current and future status of ovulation induction in polycystic ovary syndrome
Ioannis E. Messinis,S. Milingos +1 more
TL;DR: Based on the discovery of new ovarian substances which specifically control luteinizing hormone (LH) secretion, assumptions on possible implications of these substances in the pathophysiology of PCOS and their potential use in the management of the syndrome are developed.
Gonadotrophin treatment in patients with polycystic ovary syndrome
TL;DR: Although preliminary, the partial cessation of follicular development, along with regression leading to atresia, lends support to the LH ceiling theory, emphasizing the delicate balance and need for both FSH and LH in normal follicularDevelopment.
34
Urofollitropin and ovulation induction.
TL;DR: It remains unclear whether human menopausal gonadotropins have a higher risk of overstimulation and ovarian hyperstimulation syndrome compared to urofollitropin in women with polycystic ovary syndrome and if availability is not an issue but costs are, there is still a place for the use of uroFollitroins for ovulation induction.
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References
A model for follicular selection and ovulation: lessons from superovulation.
TL;DR: Current evidence suggests that ovulation occurs at random between the two ovaries in successive cycles and that the corpus luteum exerts an inhibitory effect on folliculogenesis by suppressing the secretion of FSH and LH.
202
Ovarian Responses in Macaques to Pulsatile Infusion of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone: Increased Sensitivity of the Maturing Follicle to FSH
TL;DR: Observations demonstrate that after stimulation by elevated FSH concentration, follicles can continue to mature in the presence of FSH concentrations which are unable to support the growth of less mature follicles, which may account for the mechanisms by which the maturing follicle continues to develop during the mid-through late follicular phase of the menstrual cycle.
135
A comparative, randomized study of low-dose human menopausal gonadotropin and follicle-stimulating hormone in women with polycystic ovarian syndrome
TL;DR: It is shown that low-dose FSH and hMG are equally successful in inducing ovulation, suggesting that the success of treatment depends on the low dose of gonadotropin used rather than the presence or absence of luteinizing hormone in the preparation.
121
Morphological and Endocrinological Studies on Follicular Development during the Human Menstrual Cycle
TL;DR: In order to clarify the morphological dynamics of follicular development and its correlation with ovarian endocrine activity, the present studies were performed in 45 regularly menstruating women who underwent gynecological surgery.
91
Ultrasound in the evaluation of normal and induced ovulation.
TL;DR: In the past several years sonography has become an invaluable research tool for the investigation of spontaneous and induced ovulation and has added to the understanding of folliculogenesis and reproductive endocrinology.
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