Journal Article10.1021/JA9706256
The First Formal Asymmetric Synthesis of Phorbol
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About: This article is published in Journal of the American Chemical Society. The article was published on 20 Aug 1997. The article focuses on the topics: Phorbol.
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References
Metal-promoted cyclization. 19. Novel bicyclization of enynes and diynes promoted by zirconocene derivatives and conversion of zirconabicycles into bicyclic enones via carbonylation
Ei-ichi Negishi,Steven J. Holmes,James M. Tour,Joseph A. Miller,Fredrik E. Cederbaum,Douglas R. Swanson,Tamotsu Takahashi +6 more
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A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1
Kirk R. Gustafson,John H. Cardellina,James B. McMahon,Robert J. Gulakowski,Junichi Ishitoya,Zoltan Szallasi,Nancy E. Lewin,Peter M. Blumberg,Owen S. Weislow +8 more
TL;DR: Extracts of Homalanthus nutans, a plant used in Samoan herbal medicine, exhibited potent activity in an in vitro, tetrazolium-based assay which detects the inhibition of the cytopathic effects of human immunodeficiency virus (HIV-1).
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Stereoselective cyclization of enynes mediated by metallocene reagents
TL;DR: Les enynes-1,6 and -1,7 sont efficacement cyclisees en metallacyclopentenes bicycliques avec Cp 2 TiCl 2 /PMePh 2 /Na(Hg), cp 2 ZrCl 2/Mg(HG) et Cp2 ZCl 2 2 /2BuLi.
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