Journal Article10.1016/J.JCONREL.2020.11.007
The emerging landscape of nanotheranostic-based diagnosis and therapy for osteoarthritis
Shuyi Xiao,Liang Chen +1 more
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TL;DR: In this review, different imaging targets-based nanoprobe for early and timely OA diagnosis is discussed, and it is believed that nanoprobe and nanomedicine will become prospective in OA therapeutic revolution.
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About: This article is published in Journal of Controlled Release. The article was published on 08 Nov 2020.
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Citations
Design, Printing, and Engineering of Regenerative Biomaterials for Personalized Bone Healthcare
TL;DR: Recently, the convergence of additive manufacturing (AM) and bone tissue engineering (BTE) has opened up an era of personalized bone healthcare, wherein "design", "printing" and "engineering" inputs are judiciously orchestrated to yield custom 3D architected (bio)scaffolds, per relevant AM paradigms, to address biological/pathological complexities of host tissues as mentioned in this paper .
73
Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis.
TL;DR: In this article, the authors explored the biological roles and underlying mechanism of MSCs-EVs in osteoarthritis (OA) and found that EVs-circHIPK3 participated in MSC-EV-mediated chondrocyte proliferation and migration induction and in chondromycocyte apoptosis inhibition via the miR-124-3p/MYH9 axis.
Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy.
Longfa Kou,Huirong Huang,Ying Zhong Tang,Meng Sun,Yingtao Li,Jianing Wu,Shimin Zheng,Xin Zhao,Daosen Chen,Zucheng Luo,Xiaolei Zhang,Qing Yao,Ruijie Chen +12 more
TL;DR: In this paper , a novel opsonization trapping strategy for osteoarthritis drug delivery and treatment is proposed, which transforms a normal nanoparticle into an opsonized attractant to target and regulate macrophage polarization.
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Nerve Growth Factor-Targeted Molecular Theranostics Based on Molybdenum Disulfide Nanosheet-Coated Gold Nanorods (MoS2-AuNR) for Osteoarthritis Pain.
TL;DR: In this paper, a theranostic nanoprobe based on molybdenum disulfide nanosheet-coated gold nanorods (MoS2-AuNR) targeting never growth factor (NGF), a key player in pain sensation, was introduced for photoacoustic pain imaging and near-infrared (NIR) imaging-guided photothermal analgesic therapy.
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Modulating Pt nanozyme by using isolated cobalt atoms to enhance catalytic activity for alleviating osteoarthritis
Xin Yang,Jianhui Xiang,Wei Su,Jia Guo,Jiejia Deng,Lijuan Tang,Guanhua Li,Yanling Liang,Li Zheng,Maolin He,Jingping Zhong,Jinmin Zhao +11 more
TL;DR: In this paper , a polyatomic SOD and CAT-mimicking nanozyme composed of ultrafine Pt NPs and Co-SA-NSG with atomically dispersed Co and N, S co-doped graphene for OA treatment.
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References
Nanoparticle therapeutics: an emerging treatment modality for cancer
TL;DR: The features of nanoparticle therapeutics that distinguish them from previous anticancer therapies are highlighted, and how these features provide the potential for therapeutic effects that are not achievable with other modalities are described.
4.3K
Doxil®--the first FDA-approved nano-drug: lessons learned.
TL;DR: This review summarizes historical and scientific perspectives of Doxil development and lessons learned from its development and 20 years of its use and demonstrates the obligatory need for applying an understanding of the cross talk between physicochemical, nano-technological, and biological principles.
3.9K
The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
Marita Cross,Emma Smith,Damian G Hoy,Sandra Nolte,Ilana N. Ackerman,Marlene Fransen,Lisa Bridgett,Sean R.M. Williams,Francis Guillemin,Christopher Hill,Laura L Laslett,Graeme Jones,Flavia M. Cicuttini,Richard H. Osborne,Theo Vos,Rachelle Buchbinder,Anthony D. Woolf,Lyn March +17 more
TL;DR: In this article, the global burden of hip and knee OA was estimated as part of the Global Burden of Disease 2010 study and the burden of OA compared with other conditions.
3.1K
Extracellular vesicles: biology and emerging therapeutic opportunities
TL;DR: Recent progress in understanding extracellular vesicle biology and the role of extrace cellular vesicles in disease is reviewed, emerging therapeutic opportunities are discussed and the associated challenges are considered.
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
TL;DR: The current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA is discussed and the potential of anticytokine therapy in the treatment of this disease is addressed.
2.5K