Journal Article10.4088/jcp.21r13969
The Effect of Repetitive Transcranial Magnetic Stimulation on Suicidal Ideation in Treatment-Resistant Depression: A Meta-Analysis.
Shobhana Mehta,Gerasimos N. Konstantinou,Cory R. Weissman,Zafiris J. Daskalakis,Daphne Voineskos,Jonathan Downar,Benoit H. Mulsant,Daniel M. Blumberger +7 more
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TL;DR: The findings suggest that rTMS may be an effective treatment for SI in individuals with treatment-resistant depression, although further investigation is warranted.
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Abstract: Objective: To quantitatively synthesize the literature on the effects of repetitive transcranial magnetic stimulation (rTMS) on suicidal ideation (SI) in patients with treatment-resistant depression.
Data Sources: A literature search was conducted using PubMed, SCOPUS, Ovid, MEDLINE, Embase, and Web of Science from inception to January 11, 2021, for the keywords repetitive transcranial magnetic stimulation, suicidal ideation, suicidality, treatment-resistant depression, refractory depression, transcranial magnetic stimulation, and brain stimulation.
Study Selection: A total of 16 publications were eligible for inclusion. Studies were included that investigated the effects of rTMS in adolescents and/or adults 16 years or older diagnosed with unipolar or bipolar depression with suicidal ideation data before and after rTMS intervention.
Data Extraction: Data were extracted and managed using Covidence. Extracted data included authors, publication year, country of origin, study design, patient demographics, primary diagnosis, comorbidities, mean age, outcome assessment instruments, detailed stimulation parameters, sham control procedures, and any serious adverse events related to SI.
Results: A quantitative analysis of effect size using Hedges g was calculated for both randomized controlled trials and all other uncontrolled trials. We found a decrease in SI scores in randomized controlled trials (g = 0.158, 95% confidence interval [CI] = -0.078 to 0.393, P = .191), although the effect was not significant. There was a significant decrease in suicidal ideation scores for uncontrolled trials (g = 0.692, 95% CI = 0.463 to 0.922, P < .001).
Conclusions: Our findings suggest that rTMS may be an effective treatment for SI in individuals with treatment-resistant depression, although further investigation is warranted.
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How to save a life: From neurobiological underpinnings to psychopharmacotherapies in the prevention of suicide.
TL;DR: In this article , a critical overview of the currently available intervention options to manage and reduce risk of suicide, including psychotherapeutic modalities, traditional medication classes also providing an up-to-date overview on the antisuicidal effects of lithium, as well as novel molecules such as esketamine and emerging medications and further molecules in development.
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Deep transcranial magnetic stimulation for treatment-resistant depression: A systematic review and meta-analysis of randomized controlled studies.
Xian-Jun Lan,Xin Hu Yang,Yu Mo,Can-Jin Deng,Xing-Bing Huang,Dong Bin Cai,Wei Zheng +6 more
TL;DR: dTMS is an effective and safe treatment strategy for the management of patients with TRD and is an effective and safe treatment strategy for the management of patients with TRD using random effects models.
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Lower Dorsal Lateral Prefrontal Cortex Functional Connectivity in Late-Life Depression With Suicidal Ideation.
Gaohong Lin,Ben Chen,Mingfeng Yang,Zhangying Wu,Jinghui Zhang,Qing Wang,Si Zhang,Yuping Ning,Xiaomei Zhong +8 more
TL;DR: In this paper , the authors investigated the functional connectivity (FC) of the dorsal lateral prefrontal cortex (DLPFC) in late-life depression (LLD) with suicidal ideation.
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Analysis of Depression Disorder with Motor Activity Time-Series Data Using Machine Learning and Deep Learning
G. Kalyani,Suneetha Manne,B. Janakiramaiah,Gopi Battineni +3 more
- 01 Jan 2023
TL;DR: Analysis of depression disorder with motor activity time-series data using machine learning and deep learning explores the association between depressed aspects connected to physical activity in daily life and depression.
Efficacy and safety of repetitive transcranial magnetic stimulation in youth with depression: a systematic review and meta-analysis of randomized sham-controlled trials
Yu-Jie Tao,Xiao Xia Duan,Liu Pei,Mei-Wen Wang,Si-xun Li,ting ting luo,Hao-Yang Xing,Yi Huang,Yu-Jie Tao,Xiao Xia Duan,Liu Pei,Mei-Wen Wang,Si-xun Li,ting ting luo,Hao-Yang Xing,Yi Huang +15 more
Abstract: Abstract Background Major depressive disorder is a major cause of disability and health-related burden globally. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative therapy for major depressive disorder in adults, but its efficacy and safety in 10–25 years (youth) with depression remains inconclusive. We aim to evaluate the efficacy and safety of rTMS in youth with depression in randomized sham-controlled trials. Methods A comprehensive search of nine databases was conducted from inception to April 30, 2025. Trials using random assignment with a sham control group were selected. Heterogeneity among studies was assessed using the I 2 and Cochran Q test. A random-effects model was employed when I 2 > 50%. Standard mean deviation (SMD) for depression rating scale scores and risk difference (RD) with corresponding 95% confidence intervals (CIs) of adverse event were used to evaluate efficacy and safety, respectively. Results Sixteen studies with 1295 patients aged 10–25 years were included. Meta-analysis showed that active rTMS significantly reduced depression scale scores (SMD = – 0.93, 95% CI = – 1.31 to – 0.55). Subgroup analysis revealed significant relief of depressive symptoms at the second week (SMD = – 0.66, 95% CI = – 1.25 to – 0.07) and persisting at the fourth week (SMD = – 1.28, 95% CI = – 1.82 to – 0.75) when compared to sham stimulation. Pooled RR was 1.24 (95% CI = 1.06–1.45) for response rate and 1.63 (95% CI = 1.11–2.39) for remission rate (with an associated number needed to treat of 10). Conclusions Evidence indicates that rTMS is effective, safe and exhibits a relatively rapid onset of action for treating youth depression. Larger-scale studies with longer treatment durations and extended follow-up periods are essential to understand and characterize the short- and long-term neuromodulatory effects within this vulnerable population. The effect of rTMS in treatment-resistant depression and its use across diverse populations also need further investigation. Graphical Abstract