Journal Article10.1007/S00421-012-2442-5
The effect of acute exercise in hypoxia on flow-mediated vasodilation.
Keisho Katayama,Osamu Fujita,Motoyuki Iemitsu,Hiroshi Kawano,Erika Iwamoto,Mitsuru Saito,Koji Ishida +6 more
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TL;DR: The results suggest that aerobic exercise in hypoxia has a significant impact on endothelial-mediated vasodilation.
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Abstract: The purpose of this study was to clarify the effect of acute exercise in hypoxia on flow-mediated vasodilation (FMD). Eight males participated in this study. Two maximal exercise tests were performed using arm cycle ergometry to estimate peak oxygen uptake [Formula: see text] while breathing normoxic [inspired O(2) fraction (FIO(2)) = 0.21] or hypoxic (FIO(2) = 0.12) gas mixtures. Next, subjects performed submaximal exercise at the same relative exercise intensity [Formula: see text] in normoxia or hypoxia for 30 min. Before (Pre) and after exercise (Post 5, 30, and 60 min), brachial artery FMD was measured during reactive hyperemia by ultrasound under normoxic conditions. FMD was estimated as the percent (%) rise in the peak diameter from the baseline value at prior occlusion at each FMD measurement (%FMD). The area under the curve for the shear rate stimulus (SR(AUC)) was calculated in each measurement, and each %FMD value was normalized to SR(AUC) (normalized FMD). %FMD and normalized FMD decreased significantly (P < 0.05) immediately after exercise in both condition (mean ± SE, FMD, normoxic trial, Pre: 8.85 ± 0.58 %, Post 5: -0.01 ± 1.30 %, hypoxic trial, Pre: 8.84 ± 0.63 %, Post 5: 2.56 ± 0.83 %). At Post 30 and 60, %FMD and normalized FMD returned gradually to pre-exercise levels in both trials (FMD, normoxic trial, Post 30: 1.51 ± 0.68 %, Post 60: 2.99 ± 0.79 %; hypoxic trial, Post 30: 4.57 ± 0.78 %, Post 60: 6.15 ± 1.20 %). %FMD and normalized FMD following hypoxic exercise (at Post 5, 30, and 60) were significantly (P < 0.05) higher than after normoxic exercise. These results suggest that aerobic exercise in hypoxia has a significant impact on endothelial-mediated vasodilation.
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Citations
Effects of acute exercise on flow-mediated dilatation in healthy humans
Ellen A. Dawson,Daniel J. Green,Daniel J. Green,N. Timothy Cable,Dick H. J. Thijssen,Dick H. J. Thijssen +5 more
TL;DR: This synthesis summarizes and integrates knowledge derived from papers relating acute impacts of exercise on artery function, specifically endothelial function assessed by flow-mediated dilatation, and proposes that an immediate decrease in FMD occurs soon after exercise cessation and that this is followed by a (supra)normalization response.
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Limitation of Maximal Heart Rate in Hypoxia: Mechanisms and Clinical Importance.
TL;DR: In this paper, a literature review emphasizes that HRmax decreases progressively with increasing hypoxia, due to an over activity of the parasympathetic nervous system, and the dose-response is roughly linear and starts at a low altitude, with large inter-study variabilities.
Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women.
Cemal Ozemek,Kerry L. Hildreth,Patrick J. Blatchford,Hurt Kj,Rachael Bok,Douglas R. Seals,Wendy M. Kohrt,Wendy M. Kohrt,Kerrie L. Moreau,Kerrie L. Moreau +9 more
TL;DR: Although resveratrol improved basal FMD, there was no apparent enhancement of FMD to the acute exercise and therefore may not act as an estradiol mimetic.
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Vascular and oxygenation responses of local ischemia and systemic hypoxia during arm cycling repeated sprints.
TL;DR: By combining high-intensity, repeated sprint exercise with BFR and/or systemic hypoxia, there is a robust stimulus detected by increased changes in blood perfusion placed on specific vascular mechanisms, which were more prominent in BFR conditions.
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Impact of hypoxic versus normoxic training on physical fitness and vasculature in diabetes.
TL;DR: Contrary to the hypothesis, hypoxia does not potentiate the effect of exercise training on physical fitness, vascular function, or glucose homeostasis in type 2 diabetes.
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