Journal Article10.1016/J.JOCA.2021.04.009
The E3 ubiquitin ligase Itch limits the progression of post-traumatic osteoarthritis in mice by inhibiting macrophage polarization.
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TL;DR: In this paper, the negative regulator of inflammation, E3 ligase Itch, was found to contribute to joint OA tissue damage by promoting pro-inflammatory polarization of macrophages.
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About: This article is published in Osteoarthritis and Cartilage. The article was published on 30 Apr 2021. The article focuses on the topics: Macrophage polarization & Protein ubiquitination.
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Citations
Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis.
Weiyun Wang,Yaru Chu,Pengyuan Zhang,Zhuo Liang,Zhenlin Fan,Xueqiang Guo,Guang Sen Zhou,Wenjie Ren +7 more
TL;DR: In this article , the molecular mechanisms of macrophage polarization and its key role in the development of osteoarthritis were described and summarized, including small molecule compounds (conventional western medicine and synthetic compounds, monomer compounds of traditional Chinese medicine), biomacromolecules, metal/metal oxides, cells and cell derivatives.
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Post-traumatic osteoarthritis: A review of pathogenic mechanisms and novel targets for mitigation
TL;DR: In this article , a review discusses new advances in our understanding of cellular mechanisms underlying post-traumatic osteoarthritis, and therapeutic approaches that are potentially effective in reducing the self-propagating cycle of subchondral bone alterations, inflammation, and cartilage degradation.
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The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway
Zhenglin Zhu,Shengqiang Gao,Cheng Chen,Wei Xu,Peng-Cheng Xiao,Zhiyu Chen,C. Du,Bowen Chen,Yanzhi Gao,Chunli Wang,Junyi Liao,Wei Huang +11 more
TL;DR: In this article , the effects and mechanisms of the small molecular drug salicin (SA) on osteoarthritis (OA) progression were investigated in a rat OA model and the effect of intra-articular injection of SA on OA progression was evaluated using RNA sequencing, molecular docking and target stability analyses.
Recent Advances in Small Molecule Inhibitors for the Treatment of Osteoarthritis
Jianjing Lin,Shi Qian Jia,Weifei Zhang,Mengyuan Nian,Peng Liu,Li Yang,Jianwei Zuo,Wei Lin,Hui Zeng,Xintao Zhang +9 more
TL;DR: In this article , small molecule inhibitors targeting MMPs, ADAMTS, IL-1, TNF, WNT, NF-κB, and other proteins were reviewed and discussed disease-modifying osteoarthritis drugs based on them.
Immunoregulation of synovial macrophages for the treatment of osteoarthritis
Mingze Xu,Yunhan Ji +1 more
TL;DR: In this article , the role of synovial macrophages in the pathogenesis of osteoarthritis is discussed, and novel therapeutic targets for preventing the progress of OA or promoting cartilage repair and regeneration are proposed.
References
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