The cyclin-dependent kinase inhibitor, p27, has no correlation with the malignant potential of GIST.

TL;DR: The p27/kip-1 protein plays a fundamental role in the development of these neoplasms and its aberrant cytoplasmic location would favour the proliferation of stem cells, which would explain both dual phenotype with presence of myoepithelial cells without connection with the bronchial tree and TTF-1 immunostaining in epithelial cells.

TL;DR: It is demonstrated, for the first time, that Skp2 expression correlates with Ki67 expression and high risk in GIST, and that high cellularity, presence of necrosis, and Ki67 overexpression were predictive of a reduced overall survival in a univariate model.

TL;DR: It was found that the clinical stage and grade were strongly associated with prognosis and patients in clinical stage II were of the highest degree of malignancy regardless of the number of parameters.

TL;DR: The data suggest that, in addition to high risk classification, cyclin H expression might be an indicator for "very-high risk" GIST, which is still a controversial issue.

TL;DR: It is concluded that gastrointestinal stromal tumors show striking morphological and immunophenotypic similarities with ICC and that they may originate from stem cells that differentiate toward a pacemaker cell phenotype and it is proposed that the noncommittal name "gastrointestinal stromic tumor" be replaced by gastrointestinal pacemaker Cell tumor.

TL;DR: The results of this study indicate that many gastric wall tumors are not derived from smooth muscle, and suggests that the myenteric nervous system is a possible source for perineurial or mesenchymal nerve sheath cells with distinctive fine structure.

TL;DR: It was found that carcinomas with low or absent p27 protein displayed enhanced proteolytic activity specific for p27, suggesting that low p27 expression can result from increased proteasome-mediated degradation rather than altered gene expression.