The Combined Regulation of Long Non-coding RNA and RNA-Binding Proteins in Atherosclerosis.
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TL;DR: In this paper, a review summarizes the important contributions of long non-coding RNAs and RNA-binding proteins in atherosclerosis and provides novel and comprehensible interaction models of lncRNAs and RBPs.
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Abstract: Atherosclerosis is a complex disease closely related to the function of endothelial cells (ECs), monocytes/macrophages, and vascular smooth muscle cells (VSMCs). Despite a good understanding of the pathogenesis of atherosclerosis, the underlying molecular mechanisms are still only poorly understood. Therefore, atherosclerosis continues to be an important clinical issue worthy of further research. Recent evidence has shown that long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) can serve as important regulators of cellular function in atherosclerosis. Besides, several studies have shown that lncRNAs are partly dependent on the specific interaction with RBPs to exert their function. This review summarizes the important contributions of lncRNAs and RBPs in atherosclerosis and provides novel and comprehensible interaction models of lncRNAs and RBPs.
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TL;DR: The atherogenic roles of GAS5 and ANXA2 in the inflammatory response of macrophages was found to be mediated by GAS5-ANXA2 regulation, opening new avenues for atherosclerosis therapy.
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The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis
TL;DR: Mechanistically, human antigen R (HuR), an RNA-binding protein, was shown to be critical for the regulation of TMOD4 by LEPIS, and overexpression of LEPis promoted the shuttling of HuR from the nucleus to the cytoplasm, enhanced the stability of TMod4 mRNA, and in turn promoted the expression of TM OD4.
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