The CF-Sputum Induction Trial (CF-SpIT) to assess lower airway bacterial sampling in young children with cystic fibrosis: a prospective internally controlled interventional trial
Katherine Ronchetti,Jo-Dee Tame,C. Paisey,Lena P Thia,Iolo Doull,Robin Howe,Eshwar Mahenthiralingam,Julian Forton,Julian Forton +8 more
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TL;DR: In this article, the role of sputum induction as a diagnostic tool for infection has not previously been systematically addressed in young children with cystic fibrosis, and the authors aimed to assess the pathogen yield from sputuma induction compared with that from cough swab and single-lobe, two-lanobe, and six-lanobescale bronchoalveolar lavage.
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About: This article is published in The Lancet Respiratory Medicine. The article was published on 01 Jun 2018. and is currently open access. The article focuses on the topics: Sputum & Bronchoalveolar lavage.
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Citations
The future of cystic fibrosis care: a global perspective
Scott C. Bell,Marcus A. Mall,Hector H. Gutierrez,Milan Macek,Susan Madge,Jane C. Davies,Pierre-Régis Burgel,Elizabeth Tullis,Claudio Castaños,Carlo Castellani,Catherine A. Byrnes,Fiona Cathcart,Sanjay H. Chotirmall,Rebecca Cosgriff,Irmgard Eichler,Isabelle Fajac,Christopher H. Goss,Pavel Drevinek,Philip M. Farrell,Anna M. Gravelle,Trudy Havermans,Nicole Mayer-Hamblett,Nataliya Kashirskaya,Eitan Kerem,Joseph L. Mathew,Edward F. McKone,Lutz Naehrlich,Samya Z. Nasr,Gabriela R. Oates,Ciaran O'Neill,Ulrike Pypops,Karen S. Raraigh,Steven M. Rowe,Kevin W Southern,Sheila Sivam,Anne L. Stephenson,Anne L. Stephenson,Marco Zampoli,Felix Ratjen +38 more
TL;DR: Advances in clinical care have been multifaceted and include earlier diagnosis through the implementation of newborn screening programmes, formalised airway clearance therapy, and reduced malnutrition through the use of effective pancreatic enzyme replacement and a high-energy, high-protein diet.
601
Novel coronavirus infection in children outside of Wuhan, China.
Qinxue Shen,Wei Guo,Ting Guo,Jinhua Li,Wenlong He,Shanshan Ni,Xiaoli Ouyang,Jiyang Liu,Yuanlin Xie,Xin Tan,Zhiguo Zhou,Hong Peng +11 more
TL;DR: Since December 8, 2019, an epidemic of coronavirus disease 2019 (CO VID‐19) has spread rapidly, but information about children with COVID‐19 is limited.
114
The Microbiome in Cystic Fibrosis Pulmonary Disease.
TL;DR: Describing of pathological microbiomes and correlation with clinical status and therapeutics revealed the richness of microbiome data, enabling description of predictive and follow-up biomarkers in cystic fibrosis.
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Sustained Coinfections with Staphylococcus aureus and Pseudomonas aeruginosa in Cystic Fibrosis
Anthony J. Fischer,Sachinkumar B. Singh,Mason M LaMarche,Lucas J Maakestad,Zoe E Kienenberger,Tahuanty Pena,David A. Stoltz,Dominique H. Limoli +7 more
TL;DR: A longitudinal cohort of children and adults with CF who had quantitative sputum cultures found no pattern of replacement of S. aureus by P. aeruginosa, and culture abundance was stable over time for both organisms.
74
Recurrent Severe Preschool Wheeze: From Prespecified Diagnostic Labels to Underlying Endotypes
Polly F. M. Robinson,Sara Fontanella,Sachin Ananth,Aldara Martin Alonso,James Cook,Daphne Kaya-de Vries,Luisa Polo Silveira,Lisa G. Gregory,Clare M. Lloyd,Louise Fleming,Andrew Bush,Adnan Custovic,Sejal Saglani +12 more
TL;DR: In this article, the authors investigated lower airway inflammation and infection in preschool children with differences in their breathing patterns. But the underlying mechanisms of preschool wheezing are poorly understood.
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