Open AccessJournal Article
The BPD Problem
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TL;DR: The laudable goal of attempting to predict the risk of "bronchopulmonary dysplasia" (defined solely as a requirement for supplemental oxygen at 28 days) to select better infants who might benefit from interventions to reduce the frequency of this chronic lung disease is undertaken.
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Abstract: To the Editor.— Sinkin and co-workers1 undertook the laudable goal of attempting to predict the risk of "bronchopulmonary dysplasia" (defined solely as a requirement for supplemental oxygen at 28 days) to select better infants who might benefit from interventions to reduce the frequency of this chronic lung disease. Other investigators have defined risk of bronchopulmonary dysplasia (BPD) in the first days to weeks of life using similar statistical analyses,2,3 cytopathology,4 detection of elevated proteases in airway secretions,5-7 measurement of airways mechanics,8,9 and clinical and radiographic scores.10,11
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Citations
A new radiographic scoring system for bronchopulmonary dysplasia
TL;DR: A simple, clinically meaningful radiographic score for bronchopulmonary dysplasia (BPD) is developed and gives results similar to the Edwards score, which plays a standardizing role in assessing severity of BPD between hospitals.
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Prognostic implications of age at detection of air leak in very low birth weight infants requiring ventilatory support
TL;DR: Air leak in newborn infants requiring mechanical ventilation is associated with increased risks of death or future morbidity, but the magnitude of these risks changes with postnatal age at the time of diagnosis of the air leak.
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Ureaplasma urealyticum infections in the perinatal period
TL;DR: Ureaplasma urealyticum is a microorganism that frequently is recovered from the female lower genital tract as mentioned in this paper and has been linked to peripartum infections in both mothers and neonates.
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Role of cytokines in hyperoxia mediated inflammation in the developing lung.
Porus Bustani,Sailesh Kotecha +1 more
TL;DR: The treatment of CLD is currently centered on the suppression of cytokine production, but more specific targets are being developed which aim to reduce the oxidative load on the lung, and prevent recruitment of inflammatory cells that are responsible for the tissue damage underlying this disease.
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Growth and nutrition in children with established bronchopulmonary dysplasia: A review of the literature.
S. E. Bauer,Katie Huff,Charles Vanderpool,Rebecca Rose,A. Ioana Cristea +4 more
TL;DR: Despite a large body of literature describing the role of growth and nutrition in the prevention of BPD, research is lacking with respect to interventions and management in the population with established BPD.
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