Journal Article10.1039/A815653Y
The biosynthesis of steroids and triterpenoids
96
About: This article is published in Natural Product Reports. The article was published on 01 Jan 1998.
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Citations
Control and biochemical nature of the ecdysteroidogenic pathway.
TL;DR: This review concerns three aspects of ecdysteroidogenesis: how the brain neuropeptide prothoracicotropic hormone initiates a transductory cascade in cells of the protharacic gland, which results in an increased rate of ecdysone biosynthesis and a series of reactions only now being understood because of the use of a combination of classical biochemistry and molecular genetics.
515
Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis.
James T. Warren,Anna Petryk,Guillermo Marqués,Jean-Philippe Parvy,Tetsuro Shinoda,Kyo Itoyama,Jun Kobayashi,Michael Jarcho,Yutai Li,Michael B. O'Connor,Michael B. O'Connor,Chantal Dauphin-Villemant,Lawrence I. Gilbert +12 more
TL;DR: The identity of the Drosophila gene phantom (phm), located at 17D1 of the X chromosome, as encoding the microsomal 25-hydroxylase (Cyp306a1) is reported, and in situ developmental gene analysis, in addition to northern, western and RT-PCR techniques, are consistent with this identification.
286
What can a chemist learn from nature's macrocycles?--a brief, conceptual view.
TL;DR: The underlying principles of the chemical diversity are reviewed in terms of biosynthetic origin and nature’s strategies for diversity and complexity generation in relation to the structural diversity and similarities found in the macrocycle database.
218
Epoxide‐Opening Cascades in the Synthesis of Polycyclic Polyether Natural Products
TL;DR: This review summarizes how epoxide-opening cascade reactions have been used in the synthesis of polycyclic polyethers and related natural products.
Ecdysteroid Chemistry and Biochemistry
René Lafont,Chantal Dauphin-Villemant,James T. Warren,Huw H. Rees +3 more
- 01 Jan 2012
TL;DR: In this article, the authors focus on the techniques used for ecdysteroid analysis and the biosynthesis and metabolism of these hormones, and the greatest diversity has been found in the eggs/embryos of Orthoptera and Lepidoptera.
187
References
Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate.
TL;DR: Results confirmed the earlier results obtained by incorporation of 13C-labelled acetate into the hopanoids of other bacteria and led to the identification of a novel biosynthetic route for the early steps of isoprenoid biosynthesis.
Bile acid biosynthesis
TL;DR: To conclude, the last several years have seen a resurgence of interest in the biosynthesis of bile acids due to the central roles that these molecules play in cholesterol and fat metabolism and due to recent advances in their chemistry, biochemistry, and molecular biology.
779
Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.
TL;DR: Surprisingly, it is found that E. coli contain an electron-transport system that can substitute for the mammalian microsomal NADPH-cytochrome P450 reductase in supporting both the 17 alpha-hydroxylase and 17,20-lyase activities of P45017 alpha.
580
Steroidogenic enzymes : structure, function, and role in regulation of steroid hormone biosynthesis
TL;DR: The final part of the review on regulation of steroidogenesis includes a description of the normal physiological fluctuations in the steroid output of adrenal cortex and gonads, and provides an analysis of the relative role of enzyme levels in the determination of these fluctuations.
555
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.
TL;DR: Both enzymes expressed in COS cells showed similar substrate specificities for naturally occurring steroid hormones, however, synthetic 4-azasteroids demonstrated marked differences in their abilities to inhibit the human and rat steroid 5 alpha-reductases.
512