Journal Article10.1038/S41590-019-0444-8
The biology and functional importance of MAIT cells.
Dale I. Godfrey,Hui-Fern Koay,Hui-Fern Koay,James McCluskey,Nicholas A Gherardin,Nicholas A Gherardin +5 more
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TL;DR: Evidence showing that MAIT cells are a key component of the immune system is reviewed and their basic biology, development, role in disease and immunotherapeutic potential is discussed.
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Abstract: In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for microbial riboflavin-derivative antigens presented by the major histocompatibility complex (MHC) class I-like protein MR1. MAIT cells use a limited T cell antigen receptor (TCR) repertoire with public antigen specificities that are conserved across species. They can be activated by TCR-dependent and TCR-independent mechanisms and exhibit rapid, innate-like effector responses. Here we review evidence showing that MAIT cells are a key component of the immune system and discuss their basic biology, development, role in disease and immunotherapeutic potential.
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MR1 presents microbial vitamin B metabolites to MAIT cells
Lars Kjer-Nielsen,Onisha Patel,Alexandra J. Corbett,Jérôme Le Nours,Jérôme Le Nours,Bronwyn S. Meehan,Ligong Liu,Mugdha Bhati,Zhenjun Chen,Lyudmila Kostenko,Rangsima Reantragoon,Nicholas A. Williamson,Anthony W. Purcell,Anthony W. Purcell,Nadine L. Dudek,Nadine L. Dudek,Malcolm J. McConville,Richard A. J. O'Hair,George N. Khairallah,Dale I. Godfrey,David P. Fairlie,Jamie Rossjohn,Jamie Rossjohn,Jamie Rossjohn,James McCluskey +24 more
TL;DR: It is shown that metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance, and data suggest that MAIT cells use these metabolites to detect microbial infection.
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Emmanuel Treiner,Livine Duban,Seiamak Bahram,Mirjana Radosavljevic,Valérie Wanner,Florence Tilloy,Pierre Affaticati,Susan Gilfillan,Olivier Lantz +8 more
TL;DR: It is shown that T cells that express the canonical hVα7.2-Jα33 or mVα19-J α33 TCR rearrangement are preferentially located in the gut lamina propria of humans and mice, respectively, and are therefore genuine mucosal-associated invariant T (MAIT) cells.
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