Journal Article10.1016/J.JHAZMAT.2018.06.003
The antagonistic effect of selenium on cadmium-induced apoptosis via PPAR-γ/PI3K/Akt pathway in chicken pancreas.
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TL;DR: The study revealed that Cd could impact the pancreas function and induce the activation of Bax and the overproduction of NO via PPAR-γ/PI3K/Akt pathway to promote apoptosis in chicken pancrea, however, Se could reduce Cd accumulation and antagonize Cd-triggered apoptosisIn chicken pancresas.
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About: This article is published in Journal of Hazardous Materials. The article was published on 05 Sep 2018. The article focuses on the topics: PI3K/AKT/mTOR pathway & Protein kinase B.
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Citations
The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature
TL;DR: The present article aims to update and expand the role of Se in As and Cd toxicity discussed in an earlier paper, and indicates that Se may also diminish As or Cdoxicity by activation of the Nrf2 pathway.
PPARs as Nuclear Receptors for Nutrient and Energy Metabolism.
TL;DR: The complex roles of PPARs in metabolic networks keep these factors in the forefront of research because it is hoped that they will have potential therapeutic effects in future applications.
180
Cadmium exposure triggers mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activation.
TL;DR: It is demonstrated that the nephrotoxicity of Cd exposure results in oxidative stress and mitochondrial dysfunction by activating the Nrf2 signaling pathway and inhibiting UPRmt in the kidneys.
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Chlorpyrifos induces the apoptosis and necroptosis of L8824 cells through the ROS/PTEN/PI3K/AKT axis
TL;DR: It is shown that CPF could trigger oxidative stress and induce apoptosis and necroptosis in fish liver cells by regulating the ROS/PTEN/PI3K/AKT axis, and the type of damage induced was dose-dependent.
152
Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload
TL;DR: In this article, up-regulation of Orai 1 and stromal interaction molecule 1 (Stim1) expression participated in the microplastics-triggered Ca2+ overload, accompanied with down-regulated of arcoplasmic reticulum Ca 2+ ATPase (SERCA).
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