Journal Article10.1016/J.MAD.2020.111257
The Aging Imageomics Study: rationale, design and baseline characteristics of the study population.
Josep Puig,Carles Biarnes,Salvador Pedraza,Joan C. Vilanova,Reinald Pamplona,José Manuel Fernández-Real,Ramon Brugada,Rafel Ramos,Gabriel Coll-de-Tuero,Laia Calvo-Perxas,Joaquín Serena,Lluís Ramió-Torrentà,Jordi Gich,Lluis Gallart,M. Portero-Otin,Angel Alberich-Bayarri,Ana Jimenez-Pastor,Eduardo Camacho-Ramos,Jordi Mayneris-Perxachs,Victor Pineda,Raquel Font,Anna Prats-Puig,Mariano-Luis Gacto,Gustavo Deco,Anira Escrichs,Bonaventura Clotet,Roger Paredes,Eugenia Negredo,Bruno Triaire,Manuel Rodríguez,Alberto Heredia-Escámez,R. Coronado,Wolter de Graaf,Valentin Prevost,Anca Mitulescu,Pepus Daunis-i-Estadella,Santiago Thió-Henestrosa,Felip Miralles,Vicent Ribas-Ripoll,Manel Puig-Domingo,Marco Essig,Chase R. Figley,Teresa D. Figley,Benedict C. Albensi,Ahmed Bilal Ashraf,Johan H. C. Reiber,Giovanni Schifitto,Uddin Md Nasir,Carlos Leiva-Salinas,Max Wintermark,Kambiz Nael,Joan Vilalta-Franch,Jordi Barretina,Josep Garre-Olmo +53 more
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TL;DR: The Aging Imageomics Study aims to identify biomarkers of human aging by analyzing imaging, biopsychosocial, cardiovascular, metabolomic, lipidomic, and microbiomic variables, and to cultivate a deeper understanding about various biological factors that underlie healthy and unhealthy aging.
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About: This article is published in Mechanisms of Ageing and Development. The article was published on 11 May 2020. The article focuses on the topics: Biomarkers of aging & Population.
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Citations
Microbiota alterations in proline metabolism impact depression.
Jordi Mayneris-Perxachs,Anna Castells-Nobau,María Arnoriaga-Rodríguez,Miquel Martin,Lisset de la Vega-Correa,Cristina Zapata,Aurelijus Burokas,Gerard Blasco,Clàudia Coll,Anira Escrichs,Carles Biarnes,José María Moreno-Navarrete,Josep Puig,Josep Garre-Olmo,Rafel Ramos,Salvador Pedraza,Ramon Brugada,Joan C. Vilanova,Joaquín Serena,Jordi Gich,Lluís Ramió-Torrentà,Vicente Pérez-Brocal,Andrés Moya,Reinald Pamplona,Joaquim Sol,Mariona Jové,Wifredo Ricart,Manuel Portero-Otin,Gustavo Deco,Rafael Maldonado,José Manuel Fernández-Real +30 more
TL;DR: In this article , a multi-omics approach combining pre-clinical models with three human cohorts including patients with mild depression was applied to find out whether microbial functions and metabolites converging onto glutamate/GABA metabolism, particularly proline, were linked to depression.
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Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans.
Jordi Mayneris-Perxachs,Anna Castells-Nobau,María Arnoriaga-Rodríguez,Josep Garre-Olmo,Josep Puig,Rafael Ramos,Francisco Martinez-Hernandez,Aurelijus Burokas,Clàudia Coll,José María Moreno-Navarrete,Cristina Zapata-Tona,Salvador Pedraza,Vicente Pérez-Brocal,Lluís Ramió-Torrentà,Wifredo Ricart,Andrés Moya,Manuel Martinez-Garcia,Rafael Maldonado,José Manuel Fernández-Real +18 more
TL;DR: The authors showed that subjects with increased Caudovirales and Siphoviridae levels in the gut microbiome had better performance in executive processes and verbal memory, while increased Microviridae levels were linked to a greater impairment in executive abilities.
84
Whole-Brain Dynamics in Aging: Disruptions in Functional Connectivity and the Role of the Rich Club.
Anira Escrichs,Carles Biarnes,Josep Garre-Olmo,José Manuel Fernández-Real,Rafel Ramos,Reinald Pamplona,Ramon Brugada,Joaquín Serena,Lluís Ramió-Torrentà,Gabriel Coll-de-Tuero,Lluis Gallart,Jordi Barretina,Joan C. Vilanova,Jordi Mayneris-Perxachs,Marco Essig,Chase R. Figley,Salvador Pedraza,Josep Puig,Gustavo Deco +18 more
TL;DR: In this paper, the authors employed two data-driven whole-brain approaches based on the phase synchronization of blood-oxygen-level-dependent signals to analyze resting-state fMRI data from 620 subjects divided into two groups (middle-age group (n = 310); age range, 50-64 years versus older group(n = 210); age ranges, 65-91 years).
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Cardiovascular Disease and Alzheimer's Disease: The Heart-Brain Axis.
Anum Saeed,Oscar Lopez,Ann Cohen,Steven E Reis +3 more
TL;DR: The current review focuses on the state of literature on molecular and metabolic pathways modulating the heart–brain axis underlying the potential association of midlife CVD risk factors and their effect on AD and related dementias.
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Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function
Jordi Mayneris-Perxachs,María Arnoriaga-Rodríguez,Josep Garre-Olmo,Josep Puig,Rafael Ramos,María Trelis,Aurelijus Burokas,Clàudia Coll,Cristina Zapata-Tona,Salvador Pedraza,Vicente Pérez-Brocal,Lluís Ramió,Wifredo Ricart,Andrés Moya,Mariona Jové,Joaquim Sol,Manuel Portero-Otin,Reinald Pamplona,Rafael Maldonado,José Manuel Fernández-Real +19 more
TL;DR: In this article , the presence of Blastocystis in the gut microbiome was associated with deficits in executive function and altered gut bacterial composition in a discovery (n = 114) and replication cohorts.
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