Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering.
Yongliang Liu,Yongliang Liu,Barunava Patra,Sanjay Singh,Priyanka Paul,Yan Zhou,Yongqing Li,Ying Wang,Sitakanta Pattanaik,Ling Yuan,Ling Yuan +10 more
TL;DR: In this paper, the authors present a comprehensive account of the influence of various biotic and abiotic factors on TIA biosynthesis and discuss possible strategies to enhance TIA production through metabolic engineering.
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Abstract: Plants synthesize a vast array of specialized metabolites that primarily contribute to their defense and survival under adverse conditions. Many of the specialized metabolites have therapeutic values as drugs. Biosynthesis of specialized metabolites is affected by environmental factors including light, temperature, drought, salinity, and nutrients, as well as pathogens and insects. These environmental factors trigger a myriad of changes in gene expression at the transcriptional and posttranscriptional levels. The dynamic changes in gene expression are mediated by several regulatory proteins that perceive and transduce the signals, leading to up- or down-regulation of the metabolic pathways. Exploring the environmental effects and related signal cascades is a strategy in metabolic engineering to produce valuable specialized metabolites. However, mechanistic studies on environmental factors affecting specialized metabolism are limited. The medicinal plant Catharanthus roseus (Madagascar periwinkle) is an important source of bioactive terpenoid indole alkaloids (TIAs), including the anticancer therapeutics vinblastine and vincristine. The emerging picture shows that various environmental factors significantly alter TIA accumulation by affecting the expression of regulatory and enzyme-encoding genes in the pathway. Compared to our understanding of the TIA pathway in response to the phytohormone jasmonate, the impacts of environmental factors on TIA biosynthesis are insufficiently studied and discussed. This review thus focuses on these aspects and discusses possible strategies for metabolic engineering of TIA biosynthesis. PURPOSE OF WORK: Catharanthus roseus is a rich source of bioactive terpenoid indole alkaloids (TIAs). The objective of this work is to present a comprehensive account of the influence of various biotic and abiotic factors on TIA biosynthesis and to discuss possible strategies to enhance TIA production through metabolic engineering.
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Citations
Light Intensity- and Spectrum-Dependent Redox Regulation of Plant Metabolism
Péter Borbély,Anna Gasperl,Tamas Palmai,Mohamed Ahres,Muhammad Asghar,Gábor Galiba,Maria Müller,Gábor Kocsy +7 more
TL;DR: A review of the current knowledge of the light-associated redox control of basic metabolic pathways (carbon, nitrogen, amino acid, sulphur, lipid, and nucleic acid metabolism), secondary metabolism (terpenoids, flavonoids, and alkaloids), and related molecular mechanisms can be found in this article .
Transcriptomic analysis of genes related to alkaloid biosynthesis and the regulation mechanism under precursor and methyl jasmonate treatment in Dendrobium officinale
TL;DR: Wang et al. as discussed by the authors collected D. officinale protocorm-like bodies (PLBs) and treated them with TIA precursors (tryptophan and secologanin) and MeJA for 0 (T0), 4 (T4) and 24 h (T24); they also established control samples (C4 and C24).
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Interplay of transcription factors orchestrating the biosynthesis of plant alkaloids
TL;DR: The present review discusses TF families, viz.
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Role of plant biotechnology in enhancement of alkaloid production from cell culture system of Catharanthus roseus: A medicinal plant with potent anti-tumor properties
None Schweizerische Gesellschaft fr Angiologie Socite Suisse dAn,Santoshi Acharjee,Raghawendra Kumar,Nitish Kumar +3 more
TL;DR: In this article, a review article discusses the in vitro techniques of genetic improvement of C. roseus and techniques adopted to analyse the biochemical factors associated with the biosynthesis pathway and shows that stress-induced culture showed several fold increases in the pharmacologically important alkaloid production.
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Deciphering the Response of Medicinal Plants to Abiotic Stressors: A Focus on Drought and Salinity
Mansoureh Nazari,Ali Akbar Ghasemi-Soloklui,Mojtaba Kordrostami,Arafat Abdel Hamed Abdel Latef +3 more
TL;DR: This review examines the impact of drought and salinity on medicinal plants, highlighting their effects on photosynthesis, growth, and productivity, and explores the protective mechanisms employed by these plants to mitigate these abiotic stresses and maintain their potency.
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