Tendon functional extracellular matrix.
TL;DR: This article reviews the three workshops held under the “Functional Extracellular Matrix” stream, which focused on the roles of the tendon extracellular matrix, such as performing the mechanical functions of tendon, creating the local cell environment, and providing cellular cues.
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About: This article is published in Journal of Orthopaedic Research. The article was published on 01 Jun 2015. and is currently open access. The article focuses on the topics: Tendon.
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Citations
Tendon injury and repair – A perspective on the basic mechanisms of tendon disease and future clinical therapy
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TL;DR: A novel framework to understand tendon physiology and pathophysiology is described that may be useful in pushing the field forward and represents a perspective on the important role that biomaterials will play in translating research discoveries to the patient.
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Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis.
Eric Gracey,Arne Burssens,Arne Burssens,Isabelle Cambré,Isabelle Cambré,Georg Schett,Rik Lories,Iain B. McInnes,Hiroshi Asahara,Dirk Elewaut,Dirk Elewaut +10 more
TL;DR: The evidence for the known role of mechanical loading in tendinopathy and its potential role in inflammatory arthritis is discussed, which potentially focuses systemic autoimmune disease on the joint in the initiating phases of SpA and RA.
Collagen VI disorders: Insights on form and function in the extracellular matrix and beyond.
TL;DR: An important role for collagen VI in obesity, cancer and diabetes is emerging and the paucity of information about how collagen VI deficiency in the extracellular matrix signals the final downstream consequences is a major barrier to developing effective therapies.
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Recent development and biomedical applications of decellularized extracellular matrix biomaterials
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Tendon development and diseases
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References
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche
Yanming Bi,Driss Ehirchiou,Tina M. Kilts,Colette A. Inkson,Mildred C. Embree,Wataru Sonoyama,Li Li,Arabella I. Leet,Byoung Moo Seo,Li Zhang,Songtao Shi,Songtao Shi,Marian F. Young +12 more
TL;DR: It is shown that human and mouse tendons harbor a unique cell population, termed tendon stem/progenitor cells (TSPCs), that has universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity and could regenerate tendon-like tissues after extended expansion in vitro and transplantation in vivo.
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Engineering Complex Tissues
TL;DR: This review highlights advances in tissue engineering technologies to enable regeneration of complex tissues and organs and to discuss how such innovative, engineered tissues can affect the clinic.
920
Elastic proteins: biological roles and mechanical properties.
John M. Gosline,Margo A. Lillie,Emily Carrington,Emily Carrington,Paul A. Guerette,Christine Ortlepp,Ken N. Savage +6 more
TL;DR: It is probable that elastic proteins will provide a wealth of chemical structures and elastic mechanisms that can be exploited in novel structural materials through biotechnology.
Fibrocartilage in tendons and ligaments — an adaptation to compressive load
TL;DR: Fibrocartilage is a dynamic tissue that disappears when the tendons are rerouted surgically and can be maintained in vitro when discs of tendon are compressed, but at some locations fibrocartilaginous is a sign of pathology.
775
The Multicomposite Structure of Tendon
TL;DR: A revised morphological model for the crimp structure of tendon is presented and small bunches of collagen fibrils removed from the tendon are shown to exhibit the simple planar zig-zag morphology described in previous literature.
685